Proteostasis and Protein Aggregation in Neurodegeneration – PPAN
NOTE: Starts with the October 2026 Council round submission dates (Cycle I due dates). This study section was evaluated as part of CSR’s ENQUIRE process to align study sections with advances in science. Learn more about ENQUIRE.
The Proteostasis and Protein Aggregation in Neurodegeneration study section reviews applications examining how defects in protein synthesis, folding, degradation and aggregation lead to neurodegeneration. Proposals examining prion mechanisms and prion-like spreading of neurotoxic proteins are also reviewed. Applications may include in vitro, ex-vivo, and/or in vivo experimental approaches but typically do not include human subjects.
Topics
- Consequences of disturbances in proteostasis and liquid-liquid phase separation in neurodegeneration: abnormal protein folding, aggregation, clearance and spreading in the context of neurodegenerative diseases.
- Delineation of cellular and physiological effects of aggregated proteins/ peptides on neuronal function.
- Characterization of abnormal protein processing associated with neurodegenerative disorders.
- Stress granule biology and compensatory/protective mechanisms
- Dipeptide repeat proteins and their mechanisms of production and toxicity
- Defects in protein synthesis, degradation, folding and posttranslational modifications leading to cell stress and neurodegeneration
- Amplification and transmission of pathogenic protein conformers.
