Metabolic, Cerebrovascular, Environmental, and Sleep Factors in Alzheimer’s Disease and Related Dementias (ADRD) – ZRG1 AN-W 55
The ZRG1 AN-W (55) special emphasis panel reviews applications studying metabolic, cerebrovascular, environmental, and sleep factors in the etiology, pathophysiology, progression, and treatment of Alzheimer’s disease and related dementias (ADRD) such as Parkinson’s dementia, Lewy body dementia (LBD), frontotemporal degeneration (FTD) and multi-etiology dementias, aging associated brain functional decline, and other neurodegenerative diseases such as Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Studies reviewed by ZRG1 AN-W (55) employ integrated experimental approaches focusing on preclinical studies but may include studies combining in vitro cellular mechanistic and in vivo tests. Experimental models typically considered include vertebrate and invertebrate animals, as well as combination of animal and human tissues.
Review Dates
Topics
- Metabolic factors and pathways involved in the etiology and pathophysiology of ADRD and neurodegenerative diseases.
- Brain-peripheral interactions such as gut-brain axis, heart-brain axis, and liver-brain axis in ADRD and neurodegeneration.
- Dysregulation of neuroendocrine function and hormonal disbalance/dysfunctions involved in ADRD and neurodegeneration.
- Blood-brain barrier and cerebrovasculature factors in ADRD. Links between cerebral amyloid angiopathy (CAA) and ADRD including vascular contributions to cognitive impairment or dementia (VICD).
- Abeta and other toxic protein clearance including glymphatic system dysfunction in ADRD and neurodegeneration.
- Long-term sequelae of hypoxic/ischemic and traumatic brain injuries and their links to ADRD and neurodegeneration.
- Environmental factors and exposure to toxins contributing to etiology of and pathophysiology associated with ADRD and neurodegeneration.
- Sleep dysregulations contributing to etiology and pathophysiology of ADRD and neurodegeneration.
