Brain Injury and Neurovascular Disorders – BIND

Topics

• Ischemic and hemorrhagic stroke, including stroke rehabilitation, management and outcomes.  
• Pathophysiological mechanisms of traumatic brain injury (TBI), including management and outcomes.   
• Small vessel cerebrovascular disease (SVD) and microvessel disease.  
• Cognitive impairment and perceptual effects secondary to stroke, TBI, SVD, vascular contributions to cognitive impairment and dementia (VCID), and intracerebral hemorrhage (ICH), including other forms of dementia.  
• Brain changes due to angiogenesis, gliosis, white matter injury, and neural rewiring, including therapies and interventions.  
• Hypoxic encephalopathy and ischemic blood brain barrier (BBB) disruption.  
• Autonomic dysfunction and other sequelae of acute brain injury.  
• Epilepsy, including refractory and drug-resistant seizure disorders; resulting from neurodegenerative processes; acute seizure disorders, including new onset refractory status epilepticus and seizures resulting from acute brain injury or within the context of injury processes. 
• Imaging based (PET, MRI, DTI, fMRI, and MRS) and electrophysiological EEG, EMG evaluation of neurological or neurobehavioral status.  

Shared Interests and Overlaps

There are shared interests in cerebrovascular disease (CVD)/TBI/hypoxic/ischemic stroke with Brain Injury and Neurovascular Pathologies (BINP), and Developmental Brain Disorders (DBD). Applications that primarily emphasize clinical and human-subject based studies (also imaging-heavy proposals in this context) are reviewed in BIND. Applications that emphasize the use of experimental and preclinical animal models are reviewed in BINP. Applications that emphasize pediatric TBI/hypoxic/ischemia (primarily neurodevelopmental effects) are reviewed in DBD. 

There are shared interests in seizures/epilepsy with Clinical Neuroplasticity and Neurotransmitters (CNNT), and Developmental Brain Disorders (DBD). Applications that emphasize adolescent/adult human studies are reviewed in BIND. Applications that emphasize animal and cellular experimental mechanistic studies are reviewed in CNNT. Applications that emphasize developmental aspects - neonate/pediatric are reviewed in DBD. 

There are shared interests in VCID with Clinical Neurodegeneration Translational Neuroscience (CNTN). Applications that emphasize cerebrovascular contributions to cognitive impairment are reviewed in BIND. Applications that emphasize cognitive decline from clinical neurodegenerative diseases are reviewed in CNTN. 

There are shared interests in VCID, SVD and TBI with Motor Function, Speech and Rehabilitation (MFSR). Applications that emphasize neurological mechanisms and outcomes are reviewed in BIND. Applications that emphasize behavioral measures and motor involvement are reviewed in MFSR.  

There are shared interests in imaging tool development with Neuro Informatics, Computational and Data Analysis (NICD). Applications that emphasize applying new imaging tools and technologies in the evaluation of neurological disorders such as stroke, epilepsy, and traumatic brain injury are reviewed in BIND. Applications that emphasize the development of novel imaging tools, modeling and data analytics are reviewed in NICD. BIND does not review applications focused on new technologies that only use the neurological disorders as an output secondary to the focus on the further development or refinement of the imaging tools.   

There are shared interests in epilepsy with Bioengineering and Tissue Engineering for Neuroscience (BTEN). Applications that emphasize evaluating the efficacy of neurological outcome measures are reviewed in BIND. Applications that emphasize the localization and monitoring of neural activity/epileptic seizure foci using invasive methods: implanted electrodes and ECoG are reviewed in BTEN.  

There are shared interests in the use of imaging and other technological methods in the study of epilepsy, TBI, stroke, and SCI with Neuromodulation and Imaging of Neuronal Circuits (NINC). Applications that emphasize evaluating the efficacy of their use as neurological outcome measures in epilepsy, TBI, stroke, and SCI are reviewed in BIND. Applications that emphasize bioengineering developments in noninvasive medical technologies, the combination of imaging modalities for brain mapping, and creation or development of computational and mathematical models are reviewed in NINC.