Hypersensitivity, Allergies and Mucosal Immunology (HAMI) – ZRG1 DCAI (57)

Topics

• Immunological mechanisms, both innate and adaptive, related to hypersensitivities and allergies, including, but not limited to, the upper and lower gastrointestinal tract, upper and lower respiratory tract, and skin.
• Studies of immune mechanism at mucosal sites using immune cells, immune epitope discovery, and/or immune methods, readouts and endpoints.
• Immunological analyses and/or immunogenetics of systemic sequelae associated with hypersensitivities, allergic diseases and/or mucosal responses.
• Immunological examination of dysregulation or homeostasis, linking mucosal immune responses with the microbiome.
• Modification and/or modulation of immunological mechanisms/responses related to hypersensitivities, allergic diseases and the mucosa.

Shared Interests and Overlaps

Applications that focus on mucosal immunology, hypersensitivity and allergic diseases that currently fit the Hypersensitivity, Autoimmune, and Immune-mediated Diseases (HAI). Standing Study Section are being moved to the HAMI Special Emphasis Panel.

There are shared interests with Innate Immunity and Inflammation (III) Study Section in innate immunity. Applications involving effector functions of innate immune cells when the focus is on hypersensitivities, allergic diseases and mucosal immunity may be assigned to HAMI. Applications more focused on inflammation and basic innate mechanisms may be assigned to III.

There are shared interests with Immunity and Host Defense (IHD) Study Section in immune responses to microbes. Applications involving innate or adaptive immune responses to environmental factors such as microbiome and non-pathogenic molecules, in the context of hypersensitivities, allergic diseases and/or mucosal immunology may be assigned to HAMI, while those involving host responses to infectious agents may be assigned to IHD.

There are shared interests with Lung Cellular, Molecular, And Immunobiology (LCMI) Study Section in immune responses in the respiratory tract. Applications studying immune cells, immune mechanisms and/or responses, either innate or adaptive, in the context of upper and lower respiratory tract-related hypersensitivities, allergic diseases, e.g., allergic asthma, may be assigned to HAMI, while those involving airway/lung pathology, airway epithelial cells, airway smooth muscle, adrenergic agonists and receptors, surfactant proteins, and genetic predisposition in the context of asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD) may be assigned to LCMI.

There are shared interests with Arthritis, Connective Tissue and Skin (ACTS) Study Section in skin-associated immune responses. Applications studying immune cells, immune mechanisms and/or responses, either innate or adaptive, in the context of skin-associated hypersensitivities, allergic diseases, may be assigned to HAMI. Applications with focus on the biology, physiology, development and homeostasis of the skin and skin appendages, may be assigned to ACTS.

There are shared interests with Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Diseases (DHMI) Study Section in the immune responses in the gastrointestinal tract. Applications studying immune cells, immune mechanisms and/or responses, either innate or adaptive, in the context of hypersensitivities and allergic diseases in the gastrointestinal tract may be assigned to HAMI. Applications involving non-allergic responses, gastrointestinal epithelial biology; barrier function; regulation of gene expression related to gastrointestinal inflammation and repair mechanisms in the context of acute and chronic gastrointestinal conditions, such as celiac disease, gastritis, necrotizing enterocolitis, may be assigned to DHMI.