The Immunity and Host Defense [IHD] study section reviews applications concerned on the innate and adaptive immune responses to a wide variety of pathogens and commensals, including viruses, bacteria, fungi, and parasites.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Host Defense and Immunity: Innate and acquired host immune responses to microorganisms and the microbiome communities; maternal/neonatal immune responses to microbes; host factors, including biochemical and genetic pathways that influence the immune responses to microbes; cells, receptors, cytokines, chemokines, and soluble mediators that provide early protection from pathogens and their products or responses to commensal organisms. Immune cells, innate and adaptive, including but not limited to NK cells, phagocytes, gamma/delta and NK T cells, B-1 cells, dendritic cells, T and B cells. Receptors including but not limited to molecules expressed by these cells engaged in innate and adaptive immunity, including chemokine and other G-protein coupled receptors, NK cell activation and inhibitory receptors, phagocytic receptors, pattern recognition receptors, adhesion receptors, co-stimulatory molecules, antigen-specific receptors and cytokine receptors.
- Mucosal immunity to microbes: host immune responses in mucosal sites to microbes and immune regulation by the microbiomes. Induction and modulation of mucosal immune responses. Comparison of mucosal immunity versus systemic immunity, differentiation of immune responses in the mucosa and peripheral lymphoid tissues, and immune cell migration to mucosal sites, including inductive and effector sites.
Shared Interests and Overlaps
There are shared interests with Innate Immunity And Inflammation (III) in innate immune responses. Applications involving effector functions of innate immune cells in response to microbial interactions as the predominant trigger may be reviewed by IHD. Applications more focused on systemic and tissue-specific inflammation and responses may be reviewed by III. In vitro and in vivo infectious disease models may be reviewed by IHD, whereas genetic animal and non-mammalian models of innate immunity, such as drosophila and zebra fish, may be reviewed by III.
There are shared interests with Vaccines against Microbial Diseases (VMD) in immune mechanisms to microbes. Applications involving the mechanisms by which immune cells respond to microbial antigens or adjuvants may be reviewed by IHD. Applications that involve development of vaccines or are focused on generation of a vaccine as the end-point may be reviewed by VMD.
There are shared interests with Hypersensitivity, Allergies and Mucosal Immunology [HAMI] Recurring Special Emphasis Panel in immune responses to microbes. Applications involving innate or adaptive host responses to the microbiome, in the context of hypersensitivities, allergic diseases and/or mucosal inflammatory diseases may be reviewed by HAMI, while those involving host responses to infectious agents may be reviewed by IHD.
There are shared interests with Pathogenic Eukaryotes Study Section (PTHE) in the response by immune cells to eukaryotic pathogens. The general mechanisms by which the immune system responds to eukaryotic pathogen persistence may be reviewed by IHD, while the genetic basis of resistance and mechanisms of pathogen/host evasion may be reviewed by PTHE.in the response by immune cells to eukaryotic pathogens. The general mechanisms by which the immune system responds to eukaryotic pathogen persistence may be reviewed by IHD, while the genetic basis of resistance and mechanisms of pathogen/host evasion may be reviewed by PTHE.
There are shared interests with Virology A & B Study Sections (VIRA & VIRB) in the response by immune cells to viruses. Genetic mechanisms of viral host evasion and identification of determinants of susceptibility or resistance may be reviewed by VIRA and VIRB. The general mechanisms by which the immune system responds to viral persistence may be reviewed by IHD.
There are shared interests with Host Interactions with Bacterial Pathogens Study Section (HIBP) in responses by immune cells tobacteria. Applications in which the focus is on the bacterium or pathogenic mechanism may be reviewed by HIBP. If the focus in on the immune response to a bacterial trigger, the application may be reviewed by IHD.
There are shared interests with Clinical Research and Field Studies of Infectious Diseases (CRFS) in consideration of the host response to infectious agents. Applications that focus on immune responses to infectious agents that include mechanisms of the host response and animal models may be reviewed by IHD. Applications that focus on population-based studies while examining immune responses to the pathogens may be reviewed by CRFS.