Clinical Endocrinology – EMS (82)

Topics

• Physiology and non-malignant disorders of endocrine organs: hypothalamic, pituitary, thyroid, and adrenal physiology, and pathophysiology; autoimmune endocrine disease.
• Neuroendocrinology: including development and mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis; anterior pituitary hormones; neurophysiology of hormones.
• Endocrinology of aging: menopause; end-organ analysis; mechanisms of endocrine longevity of hormone responsive organs e.g., breast, ovaries, prostate.
• Hormone regulation of non-malignant cell growth and differentiation events of steroid hormone responsive tissue.
• Mechanisms of puberty: Maturation and physiology of Prostate and Mammary gland development; hormonal control of lactation; prolactin.

Hormone contribution to pathological conditions: Polycystic ovary syndrome (PCOS), endometriosis, hypogonadism, precocious puberty, pituitary adenomas, and leiomyomata (fibroids), benign prostatic hyperplasia.

Shared Interests and Overlaps

There are shared interests with Cell Signaling and Molecular Endocrinology (CSME) in the investigation of signaling pathways that modulate steroid hormones action. Applications that focus on understanding synthesis, processing of steroid hormones and nuclear receptors regulation may be reviewed in CSME, whereas those that focus on hormone signaling pathways that modulate normal differentiation, growth, and function of hormone responsive tissue may be reviewed in EMS (82).

There are shared interests with Environmental Influences in Pregnancy and Offspring Health [EMS (81)] in the investigation of signaling pathways that modulate reproductive systems. Applications that focus on the investigation of environmental factors or xenobiotics effects on male and female gonads and hormone effects on fertility may be reviewed by EMS (81), whereas those that focus on translational and clinical effects of steroid hormones on normal processing may be reviewed in EMS (82).

There are shared interests with Pregnancy and Neonatology (PN) in the investigation of reproductive organs and pregnancy. Applications that focus on the effects on implantation, pregnancy complications, or fetal development may be reviewed in PN, whereas applications that focus on endocrine function may be reviewed in EMS (82).

There are shared interests with Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep (BNRS) on the hypothalamic-pituitary-gonadal (HPG) axis. Applications that focus on cognitive and behavioral outcomes may be reviewed in BNRS, whereas those that focus on the mechanisms of the HPG axis and neurophysiology of hormones may be reviewed in EMS (82).

There are shared interests with Kidney and Urological Systems Function and Dysfunction (KUFD). Applications that focus on prostate hyperplasia effects on urinary tract may be reviewed in KUFD, whereas applications that focus on prostate gland development and differentiation up to benign prostatic hyperplasia may be reviewed in EMS (82).

There are shared interests with Cellular Mechanisms in Aging and Development (CMAD) around hormone responsive tissue/organ senescence. Applications that focus on understanding lifespan and process of aging may be reviewed in CMAD, whereas applications that focus on endocrine regulation of hormone responsive organs may be reviewed in EMS (82).

Applications that focus on cancer of hormone responsive tissues (e.g. breast, ovarian, thyroid, or prostate cancer) are reviewed by the BTC, CDPT, or CTH Review Branches.