Cell Signaling and Molecular Endocrinology – CSME

Topics

• Molecular pathways involved in synthesis, processing, folding, trafficking and secretion of local and circulating peptides and steroid hormones.
• Nuclear Receptors: regulation, biochemistry and molecular mechanisms of steroid hormone action (e.g., androgen, estrogen, glucocorticoids, thyroid) and other nuclear receptors (e.g., PPARs, RXRs) receptors.
• Regulation, biochemistry and molecular mechanisms of action of (e.g. thyroid,).
• Structural, biological and biophysical interactions of G-protein-coupled, nuclear and peptide hormone receptors (e.g., insulin, glucagon).
• Hormonal regulation of gene expression: Epigenetics, chromatin structure, transcriptional regulators (e.g. DNA-binding proteins, coactivators/ corepressors), nuclear and mitochondrial transcription factors.
• Cell signaling and metabolic regulation of endocrine organs ( endocrine pancreas, pituitary, bone); energy homeostasis (e.g. mitochondria).
• Cell signaling mechanisms controlling cell function, and gene expression in metabolic tissues (liver, adipocytes, skeletal muscle).
• Signaling mechanisms and epigenetic regulation of pancreatic islets cells growth and function.

Shared Interests and Overlaps

There are shared interests with Basic Mechanism in Diabetes and Metabolism (BMDM) in the investigation of signaling pathways that regulate adipocytes and pancreatic islet cells. Applications focused on genetic determinants of pancreatic islets cells and adipocytes development and differentiation may be reviewed in BMDM, while those that focus on signaling pathways of factors that modulate pancreatic islets cells, and adipocytes growth and function may be reviewed in CSME.

There are shared interests with Clinical Endocrinology [EMS (82)] in the investigation of endocrine organ physiology. Applications focused on the regulation of non-malignant disorders of endocrine organs (pituitary, thyroid, and adrenal) may be reviewed in EMS (82), while those that focus on regulation, biochemistry and molecular mechanisms of their receptors may be reviewed in CSME.

There are shared interests with Skeletal Biology Development and Disease (SBDD) in the investigation of signaling pathways of peptide hormones and their receptors. Applications focused on paracrine factors involved in bone regulation may be reviewed in SBDD, while those that focus on steroid hormone signaling regulation of muscle and bone cells may be reviewed in CSME. 

There are shared interests with the Molecular and Integrative Signal Transduction (MIST) in the investigation of molecular mechanisms of cellular signaling. Applications focusing on basic biochemical and structural mechanisms of signal transduction, including G-proteins coupled receptors (GPCR) and their regulation may be reviewed in MIST, while applications that focus on the structural, biological and biophysical interactions of G-protein-coupled receptors in cell biology may be reviewed in CSME.

There are shared interests with the Membrane Biology and Protein Processing (MBPP) in the investigation of the regulation of protein synthesis, processing and trafficking. Applications focusing on understanding the basic mechanisms of these processes may be reviewed in MBPP, while those that focus on molecular pathways involved in the synthesis, processing, folding, trafficking and secretion of local and circulating peptides and hormones may be reviewed in CSME. 

There are shared interests with the Skeletal Muscle Biology and Exercise Physiology (SMEP) in the investigation of molecular and cellular mechanisms of skeletal muscle function. Applications focusing on biochemical and molecular biology of muscle-specific proteins, skeletal muscle adaptation, energy and substrate metabolism when skeletal muscle function is the primary focus, may be reviewed in SMEP, while those that focus on cell signaling, energy homeostasis, epigenetic mechanisms controlling cell function and gene expression in skeletal muscle may be reviewed in CSME.

There are shared interests with the Oncology focused review branches in the investigation of steroid/hormone signaling and their receptors and endocrine organs. Applications that encompass cancer initiation, promotion, progression, and metastasis, cancer prevention, diagnosis and treatment may be reviewed in one of the Oncology focused branches. Applications using cancer cells as experimental models to study mechanisms of action of hormones and nuclear receptors may be reviewed in CSME.