Chemical Synthesis & Biosynthesis – CSB
The Chemical Synthesis & Biosynthesis (CSB) study section reviews applications in the areas of fundamental methods and strategies for synthesis and biosynthesis of molecules that may contribute to advances in biology, medicine, and biotechnology. Areas broadly include synthetic methodology development, the chemistry of metals, nucleic acid, chemistry, and carbohydrate chemistry. Many objectives are relevant to early stages of drug development.
Review Dates
Topics
- Methodologies of total synthesis and target-oriented synthesis of organic, organometallic, and inorganic compounds
- Isolation, synthesis, and biosynthesis/pathway bioengineering of complex natural products
- DNA encoded synthesis and associated methodologies
- Synthesis of nucleic acids, lipids, carbohydrates, and other biologically active molecules.
- Chemistry of peptides, proteins, and their mimetics.
- Secondary metabolism of biomolecules
- Synthesis of new supramolecular species and nanomaterials for drug discovery, including dendrimers and polymers
- Mechanisms of catalysis and biocatalysis
- Synthetic and biosynthetic methodologies in structure-based drug discovery
- Machine learning / AI driven development of synthesis methodologies
Shared Interests and Overlaps
There are shared interests in targeting biological systems with synthetic molecules with Chemical Biology and Probes (CBP). Applications that emphasize development of synthetic methods are reviewed in CSB. Applications that emphasize strategic deployment in fundamental studies of biological system are reviewed in CBP.
There are shared interests in natural product biosynthesis, metal catalysis, and computational methodology with Macromolecular Structure and Function A (MSFA). Applications that use synthetic and coordination chemistry to design new metallo-reagents are reviewed in CSB. Applications that link metallo-centers to enzymatic catalysis and those examining molecular mechanisms of metal homeostasis are reviewed in MSFA. Applications that employ structural biology approaches to studying catalysis and biocatalysis are reviewed in MSFA. Applications that emphasize computational methodology not targeted specifically to synthesis are reviewed in MSFA.
There are shared interests in development of polymeric, supramolecular and nanomaterials with Innovations in Nanosystems and Nanotechnology (INN) and Drug and Biologic Therapeutic Delivery (DBTD). Applications that emphasize new basic synthetic chemistry strategies are reviewed in CSB. Applications that emphasize development of higher-level nanostructures, nanodevices, nano-biologics, or biomaterials customized for specific biomedical applications are reviewed in INN or DBTD.
There are shared interests in natural product isolation with Enabling Bioanalytical and Imaging Technologies (EBIT). Applications that emphasize overall chemistry of end products or their derivatives are reviewed in CSB. Applications that focus on developing new analytical/bioanalytical tools isolation and identification are reviewed in EBIT.
There are shared interests in the early stages of anti-infective therapeutic drug development with Drug Discovery and Molecular Pharmacology A (DMPA) and Infectious Disease Drug Development and Molecular Pharmacology [DCAI (81)]. Applications that emphasize synthetic and biosynthetic approaches with limited biological assessments are reviewed in CSB. Applications that couple synthetic approaches with extensive biological analyses may be reviewed in DMPA and DCAI (81).
