Skeletal Connective Tissue Biology – MSOS (81)
The Skeletal Connective Tissue Biology MSOS (81) study section reviews applications involving the normal biology and pathobiology of skeletal connective tissue. This includes applications focused on joint cartilage, meniscus, tendon, and ligament biology.
Review Dates
A roster for the panel will be posted here, at least 30 days prior to the review meeting
Topics
- Development, repair, and regeneration of joint cartilage, meniscus, tendon and ligament including molecular and cellular biology, biochemistry, and physiology with respect to chondrocytes, synoviocytes, tenocytes, fibroblasts, and other cell types in joints and supporting tissues.
- Mechanisms of connective tissue patterning. This includes molecular, cellular, and genetic studies; joint biology; integration of connective tissues; lineage commitment and differentiation.
- Pathogenesis of skeletal connective tissue diseases including osteoarthritis, post-traumatic osteoarthritis, rheumatoid arthritis, tendinitis, temporomandibular joint disorders, and chondrodysplasias.
- Characterization of the intrinsic capacity of cartilage, meniscus, tendon and ligament to repair and regenerate.
- Development and application of strategies to enhance repair of cartilage, tendons, and ligaments, e.g. use of small molecules, stem cells, gene therapy, biomaterials.
- Structure and organization of matrix components; cell matrix interaction and signaling.
- Mechanobiology and biomechanics of joints and ligaments.
- Biological and pathological responses associated with joint replacement including fixation, osseointegration, wear and loosening.
- Molecular mechanisms of joint pain.
