Immune Signaling and Neurologic Disorders – ISND
NOTE: Starts with the October 2026 Council round submission dates (Cycle I due dates). This study section was evaluated as part of CSR’s ENQUIRE process which functions to align study sections with advances in science. Learn more about ENQUIRE.
The ISND study section reviews innate and adaptive immune cells and signaling pathways underlying neuroinflammation, pathological aging, and neurological disorders. Areas covered will include the contributions of gene-environment interactions, environmental toxins and infections to pathological aging and neurological disorders. Most studies use in vitro and ex vivo systems, but the study section also reviews applications using in vivo studies.
Review Dates
A roster for the panel will be posted here, at least 30 days prior to the review meeting
Membership Panel
When the panel is chartered as a standing panel, members will be listed here. Expected in 2026.
Topics
- Involvement and role of microglia activation and other innate immune cells and signaling pathways in pathogenesis, neuroinflammation, pathophysiology, and progression of neurological disorders.
- • Involvement and role of adaptive immune system including activation and regulation of T cells and B cells in pathological aging and neurological disorders.
- • Involvement and role of cytokines, chemokines complement system, inflammasome in pathological aging and neurological disorders.
- • Role of gene-environment interactions and environmental toxins on immune cell function that contributes to pathological aging and neurological disorders.
- • Neuroinflammation and neuroimmune activation following bacterial and viral infections contributing to pathological aging and neurological disorders.
- Disorders studied may include but are not limited to: : Alzheimer’s disease and related dementias, epilepsy, trauma (including traumatic brain injury, peripheral nerve injury, spinal cord injury), stroke, Parkinson’s disease, Huntington’s disease, autism spectrum disorder, neurological sequalae of common infections (including COVID-19 and other viral, bacterial and fungal parasitic infections) when using in vitro or ex-vivo models
Shared Interests and Overlaps
There is overlapping and shared interest with the following review panels:
There is shared interest between CNBT and ISND in reviewing applications that study immune signaling in response to infectious disease and autoimmune diseases. Applications focus on the mechanistic aspects of these diseases are reviewed in ISND, while progression and pathogenesis involving relevant animal models/human subjects/ specimens are reviewed in CNBT.
There is significant shared interest between NP-A 85 and ISND in reviewing applications on neuroimmunology and infection. Applications that study neuroinflammation and neuroimmunology in the context of neuronal and brain injury, epilepsy, stroke using relevant animal models and human subjects are reviewed in NP-A 85 while those that are predominantly at the cellular level, in vitro or ex vivo, are reviewed in ISND.
