Special Emphasis Panel on Immunology, Inflammation and Infectious Diseases of Nervous System – ZRG1 NPA (85)

Topics

• Preclinical and translational research on neurological injury that lead to activation of immune and inflammatory responses.
• Clinical, preclinical and translational studies on neuroimmune basis of vascular cognitive impairment (VCID)
• Immunological activation of the nervous system (activation of microglia and astrocytes, infiltration of peripheral immune cells) in response to neuroinfectious diseases.
• Preclinical and clinical studies on inflammatory responses and CNS damages due to neuroinfectious diseases.
• Gut microbiome mediated inflammation in CNS in response to neuronal injury neurological disorder.
• Preclinical and clinical studies on identifying biomarkers in neuroimmune disorders
• Immune signaling and inflammation in context of blood brain barrier (BBB) dysfunction/disruption
• Clinical, preclinical and translational studies on neuroimmune basis of vascular cognitive impairment (VCID), AD, ADRD, ARIA and other disorders following neurovascular injury or damage.

Shared Interests and Overlaps

There is substantial shared interest with (CNBT) study section. Applications that focus on molecular and cellular mechanisms, developing preclinical, cellular and animal models, developing and testing therapeutic strategies modulating or modifying immunological and inflammatory processes are reviewed in CNBT while applications that emphasize on immune activation of nervous system in response to infection or injury are reviewed in NPA-85. 

There is some overlap with CPN. Applications that aim to understand the mechanisms of circuit level disorder like epilepsy, spinal cord injury and neurodegeneration are reviewed in CPN while application of these pathologies that trigger an immunological response or inflammation of the CNS can come to NPA-85

There is some shared interest between NVBC and NPA-85 study section in applications studying neurovascular disorders, brain and neuronal injury. Applications that investigate mechanisms of these disorders in context of BBB and clearance and test potential therapies in animal models are reviewed in NVBC. Application that emphasizes the role of immune system or inflammation in driving or in context of brain injury, stroke, VCID or ischemia maybe reviewed in SEP NPA-85.

There is some shared interest with NPA 81 and NPA-85 study section. Applications that investigate mechanisms of brain injury and to test potential therapies in animal models of different kinds of stroke and injury should be reviewed in NPA 81. Application that emphasizes the role of immune system or inflammation in driving or in context of brain injury, stroke, VCID or ischemia should come to NPA-85.

There is some shared interest with (DBD). Applications that are focused on developmental brain disorders in pediatric population are reviewed in DBD. Application study immune activation or immunological signaling in brain development disorder are reviewed in NPA-85.

There is shared interest between NPA-85 and BMGS in reviewing applications on neuro- infectious diseases and neuroinflammation. Applications that are focused on understanding the pathogenesis and progression of disorders that either trigger inflammation of the nervous system or are caused by neuro-infectious diseases are reviewed in NPA-85 while applications that focus on the role of glia and glial biology are reviewed in BMGS.

There is significant shared interest between NPA-85 and ISND in reviewing applications on neuroimmunology and infection. Applications that study neuroinflammation and neuroimmunology on context of neuronal and brain injury, epilepsy, stroke using relevant animal models and human subjects are reviewed in NPA-85 while those that are predominantly at the cellular, in vitro or ex vivo studies are reviewed in ISND.