Circuit Disorders, Plasticity, and Neuronal Injury – CPN

Topics

• Approaches to understand circuit-level dysfunction in epilepsy, epileptogenesis, spinal cord injury, TBI, and stroke using small animals and non-human primate models.
• Evaluation of the alteration synaptic functions, plasticity and adult neurogenesis in the above-mentioned disease models using anatomical, electrophysiological, behavioral, optogenetic, and neuroimaging technologies.
• Computer modeling methodologies to evaluate synaptic connectivity changes relating to epilepsy, spinal cord injury, TBI, and stroke.
• Changes in signal transduction pathways that accompany long term changes of excitatory and inhibitory cellular and network activity in spinal cord injury, TBI, stroke, and epilepsy
• Epigenetic processes dictating changes in neurogenesis and changes in connectivity following excitation inhibition imbalances.
• The identification of therapeutic targets and development of therapeutic strategies.
• Applications leading to the understanding of molecular changes in AMPA, GABA, NMDA and GLUR receptors in injury and alterations of excitation and inhibition.
• Mechanisms of post stroke injury adaptation and recovery
• Sleep and system level functions in injury and recovery 

Shared Interests and Overlaps

There is overlapping and shared interest with the following review panels:

There is shared interest between CPN and DBD in applications that focus on developmental aspects of circuit disorder. Applications that study neonatal/pediatric circuit-level disorders are reviewed in DBD while those that study circuit disorder in adults are reviewed in CPN.

There is shared interest between BIND and CPN study sections in applications studying brain and neuronal injury. Applications that study epilepsy, TBI, stroke, injuries of PNS and CNS in human subjects are reviewed in BIND. Applications that study the mechanistic, and preclinical aspects of circuit level dysfunction are reviewed in CPN.

There is substantial shared interest in CPN and NPA-81 in applications studying brain and neuronal injury in preclinical models. Applications on preclinical model development for TBI and stroke and some epilepsy resulting from neuronal/brain injury are reviewed both in CN81 and CPN. CN81 will review applications that are on basic mechanisms of neurovascular and neuronal injury that impact cognitive impairment, chronic and acute brain injury. Applications on injury and circuit disorder that focus on electrophysiology, optogenetics and neuroimaging  are reviewed in CPN.

There is some overlap between NVBC and CPN in applications on stroke and injury. Neurovascular injury, impact on blood brain barrier are reviewed in NVBC. TBI and stroke applications that focus on post-stroke recovery, adult neurogenesis will be reviewed in CPN.

There is significant shared interest between PMD and CPN on applications that study circuit level dysfunction. Applications that emphasize on behavioral/emotional outcome of circuit level dysfunction are reviewed in PMD while the applications that focus on mechanistic and functional aspects of circuit level dysfunction are reviewed in CPN.

There is some overlap between CPN and NPA-85 on neuro-immunological aspects of circuit level dysfunction. Applications that aim to understand the mechanisms of circuit level disorder like epilepsy, spinal cord injury and neurodegeneration are reviewed in CPN while application of these pathologies that trigger an immunological response or inflammation of the CNS can come to SEP NPA-85.

There are shared interests with CPN in stem cell biology, neurogenesis, plasticity, and regeneration of neuronal connectivity. Applications that focus on predominantly on basic cellular and molecular mechanisms of neurogenesis, synaptogenesis, plasticity, and regeneration of neuronal connectivity are reviewed in NSDR. Applications with a greater clinical and translational focus, epileptogenesis, and other circuit level disorders are reviewed in CPN.

There is shared interest between CPN and ASG in applications that focus on circuit level disorder and neuronal injury in aging populations. Applications that are focused on circuit disorder and injury (mechanistic, pre-clinical translational and clinical) in adult, but non-geriatric population are reviewed in CPN. Applications that study circuit level disorder or injury in context of age (injury related to age, diminished organ function due to aging, cognitive impairment, etc) are reviewed in ASG.

There is some shared interest between CPN and NICD on applications using computational modeling. CPN reviews applications that use computational modelling to evaluate synaptic connectivity changes related to epilepsy, stroke and neuronal injury like TBI and SCI. Applications that use Machine Learning, Brain computer interfaces, tissue modeling, artificial nerve growth in these areas are reviewed in NICD review Branch.

There is some shared interest with CPN and BMGS is applications that study basic mechanisms of circuit level disorder and injury. Applications that study basic and mechanistic aspects of neuronal-cell interactions (glia-glia/neuron glia-etc) on circuit level disorders like AD/ADRD/Epilepsy/ trauma/ PNS and CNS injury are reviewed in BMGS, while applications that will focus on electrophysiological and synaptic aspects will be reviewed in CPN.