Pathophysiological Basis of Mental Disorders and Addictions Study Section – PMDA
The PMDA Study Section reviews applications that use in vitro and animal models to investigate the pathophysiology of psychiatric, addictive and neurological disorders and the biological systems that mediate cognitive, behavioral, emotional, social and learning abnormalities. The emphasis is on an integrative biological systems understanding of the abnormalities using a wide range of molecular, genetic, biochemical, electrophysiological, pharmacological, cellular, behavioral and neuroanatomical methods. PMDA also reviews applications using human tissues when the emphasis is on molecular outcomes.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
Review Dates
Topics
- Psychiatric disorders including, schizophrenia, mood, anxiety and post-traumatic stress disorders.
- Behavioral disorders including phobias, antisocial personality, obsessive-compulsive and attention deficit disorders.
- Addictive disorders.
- Neurobiology of psychiatric manifestations in neurological disorders and chromosomal abnormalities.
- Models of neurobiological and behavioral processes and deficits that are core features of neuropsychiatric and addictive disorders.
- Neurobiological and behavioral consequences of allelic variations associated with mental disorders and their investigations in model systems.
- Genomic, genetic, epigenetic, proteomic and metabolomic studies.
Shared Interests and Overlaps
There are shared interests in childhood mental disorders/developmental psychiatric disabilities [schizophrenia] with Developmental Brain Disorders (DBD), and Neural Basis of Psychopathology, Addictions and Sleep Disorders (NPAS). Applications that emphasize mechanistic molecular and animal studies in this area are reviewed in PMDA. Human subject applications that emphasize developmental psychiatric disabilities are reviewed in DBD. Applications that focus on human studies in these areas are reviewed in NPAS.
Molecular and Cellular Substrates of Complex Brain Disorders Special Emphasis Panel [ZRG1 MDCN-P (57)] and PMDA have shared interests. Applications submitted in response to PAR-17-309 (R01) and PAR-17-310, “Cellular and Molecular Biology of Complex Brain Disorders” and applications in conflict with PMDA are assigned to ZRG1 MDCN-P (57).
Molecular Neurogenetics (MNG) and PMDA have shared interests in studies focused on genetics of addiction. MNG reviews applications where the focus is on chromatin remodeling.
Developmental Brain Disorders (DBD) and PMDA have shared interests in studies focused on developmental aspects of psychiatric disorders, including schizophrenia, with regard to developmental aspects.
Neurobiology of Motivated Behavior (NMB) and PMDA have shared interests in applications examining the Neurobiological actions of psychoactive/psychotherapeutic agents: Includes molecular and cellular mechanisms of action of psychoactive drugs on behavior.
There are shared interests in addiction and psychiatric disorders with Molecular Cellular Neuropharmacology (MCNP). Applications that emphasize the broad spectrum of issues related to addiction and mental disorders using in vitro and in vivo approaches and a variety of methods, including cellular and molecular techniques are reviewed in PMDA. Applications involving mechanisms of addiction and psychiatric disorders at the cellular and molecular level – including “-omics” data analysis are reviewed in MCNP.
