Pathophysiology of Eye Disease 2 – PED2
The Pathophysiology of Eye Disease Study Section (PED) reviews applications to investigate disorders and diseases of the eye. The science ranges from investigations of etiology, to pathogenesis, diagnosis, detection, treatment, and prevention of eye disorders and disease. PED reviews applications proposing to use human subjects or animal models of ocular disease to investigate pathophysiology or translational/clinical approaches. PED 1 and 2 are twin study sections that handle essentially the same set of topics, models, and approaches.
Review Dates
Topics
- Etiology and pathogenic mechanisms of diseases and disorders of the retina and choroid, including age-related macular degeneration (AMD), retinopathy of prematurity (ROP), diabetic retinopathy (DR), and inherited retinal degenerations, such as retinitis pigmentosa, Stargardt's Disease, Leber’s Congenital Amaurosis, etc.
- Diseases, disorders, and treatments of the ocular surface and cornea, such as wound-healing, allergies, dry eye syndrome, lacrimal and meibomian gland dysfunction, bacterial, fungal, and viral corneal infections, corneal dystrophies, Fuchs' dystrophy, keratoconus, uveal melanoma, etc.
- Understanding the pathogenesis and treatment of glaucoma (anterior and posterior) and other neuropathies.
- Neuroimmunology and inflammation associated with age-related macular degeneration, diabetic retinopathy, optic neuropathies, etc.
- All aspects of immunology, infection, and inflammation unique to the eye, such as uveitis.
- Preclinical evaluation of treatment targets and approaches, including gene therapy and stem cell-based therapy.
- Drug delivery to the ocular surface or cornea.
- Application of new technologies of imaging and visual function testing for diagnosis and monitoring of diseases and disorders of the retina and optic nerve.
- Refractive error treatments.
- Pathological aspects of retinal vasculogenesis and angiogenesis.
- Cataracts and posterior capsule opacification.
Shared Interests and Overlaps
There are shared interests with Biology and Development of the Eye (BDE). Basic biological studies of the eye that focus on the fundamental processes and mechanisms are reviewed by BDE, including studies examining the roles of known disease candidate genes in fundamental biological processes. Applications focusing on normal and abnormal retinal and ocular development are also reviewed by BDE. Applications in which the primary focus is on the etiology, pathophysiology, prevention, diagnosis, or treatment of diseases and disorders are reviewed by PED.
There are shared interests with Imaging and Bioengineering Technology for Visual Systems (IBV), Drug Discovery and Molecular Pharmacology B (DMPB), and Advancing Therapeutics B (ATB). Applications focused on the development of bioengineering approaches, therapeutic formulations, and drug delivery strategies for the treatment of ocular disorders are reviewed by IBV, whereas applications testing the applicability of these approaches and therapies for treating diseases and disorders of the retina and optic nerve using animal models or human-subject studies are reviewed by PED. Applications with a significant focus on medicinal chemistry, structural chemistry, biophysics, optimization of drug-target binding or interactions, systemic PK/PD, or safety are appropriate for DMPB or ATB.
There are shared interests with Imaging Technology for Neuroscience (ITN). Applications focused on the development of imaging methodologies are primarily reviewed by ITN, whereas applications using these methodologies to investigate diseases and disorders of the retina and optic nerve are reviewed by PED.
There are shared interests with Nervous System Development and Repair (NSDR). Applications focused on fundamental cellular and molecular mechanisms of axonal outgrowth and regeneration of neuronal connectivity following injury are reviewed by NSDR. Applications with more translational and clinical focus related to optic neuropathies and optic nerve injuries are reviewed by PED.
There are shared interests with Neuroscience of Basic Visual Process Study Section (NBVP). Applications focused on developmental mechanisms, visual information processing, cognition, and circuitry beyond the optic nerve are reviewed by NBVP. Applications that emphasize the etiology, pathophysiology, prevention, diagnosis, or treatment of eye diseases are reviewed by PED. Applications with a significant focus on disease mechanisms beyond the optic nerve may be reviewed by NBVP.
There are shared interests with Genetics of Health and Disease Study Section (GHD). Applications with a significant focus on the genetics, epigenetics, genomics, or genotype-phenotype correlations of eye diseases may be reviewed by GHD.
