The Kidney and Urological Systems Function and Dysfunction (KUFD) study section reviews applications that focus on the developmental mechanisms and function of the kidney and urinary tract, including the ureters, bladder and urethra; the male genital tract; and the visceral pelvis and pelvic floor musculature. Renal studies focus on basic and applied aspects of normal physiology, transport biology, obstructive diseases, and renal replacement including transplant and hemodialysis. Urology and urogynecology studies address both physiology and pathophysiology, including endocrine or neural influences; epidemiology, etiology and mechanisms of genitourinary disease; diagnostic strategies and biomarkers, bioengineering, and medical and surgical management, including clinical trials.
The membership will be drawn from members of other panels evaluated as part of ENQUIRE 2019. A list of members will be posted in November 2020
- Kidney epithelial and uroepithelial cell biology including mechanisms of renal transport systems; hormonal and neural regulation of renal function; and other processes relevant to normal renal physiology.
- Kidney transplantation and renal replacement therapies including basic and clinical studies of uremia, and including dialysis, kidney ablation, artificial kidneys, chronic allograft nephropathy, and prevention and/or treatment of rejection.
- Function of the bladder, ureter, and urethra and dysfunction of these and associated tissues including conditions such as lower urinary tract symptoms (LUTS), interstitial cystitis/painful bladder and pelvic pain syndromes, overactive and underactive bladder, obstructive uropathy, diabetic uropathy and neurogenic and non-neurogenic incontinence.
- Primary congenital and acquired kidney and urological conditions affecting the kidney, bladder, ureters, urethra, and genital tracts, and secondary neurogenic conditions such as spina bifida including development, epidemiology, diagnosis and management.
- Infection and inflammation in the urinary tract, including studies of susceptibility, pathogenesis and treatment of bacterial, viral and fungal infections, and the role of the genitourinary microbiome in health and disease.
- Urolithiasis and nephrolithiasis, including studies of susceptibility, pathogenesis, and treatment of upper and lower urinary tract stones.
- Function and dysfunction of the male and female genitourinary tract. Studies of the prostate and associated non-cancerous conditions such as benign prostatic hyperplasia, physiology of penile erection and the pathophysiology and treatment of erectile dysfunction; pelvic floor tissues in health and disease, including the pathogenesis and treatment of pelvic floor weakness and prolapse with associated bladder and/or bowel incontinence.
Shared Interests and Overlaps
There are shared interests with Pathobiology of Kidney Disease (PBKD). Injury or abnormalities associated with hypertension, renovascular disease, or other specific disease states may be reviewed in PBKD, while normal fluid and electrolyte transport systems may be reviewed here. Genetic mechanisms underlying specific diseases may be reviewed in PBKD, while developmental genetics of the urogenital tract may be reviewed here.
There are shared interests with Kidney, Nutrition, Obesity, and Diabetes (KNOD), which focuses on clinical and genetic epidemiological studies that focus on conditions affecting the kidney and urinary tract.
There are shared interests with Host Interactions with Bacterial Pathogens (HIBP), which focuses on the molecular basis of bacteria-host interactions and the host immune response, and with Bacterial Pathogenesis (BACP), which reviews applications that address determinants of bacterial pathogenesis. However, these study sections do not focus specifically on the pathogenesis of genitourinary infections.
Applications that focus on frank cancer of the kidney and urogenital tract (e.g. prostate or bladder cancer) are reviewed elsewhere.