Pathobiology of Kidney Disease – PBKD

Topics

• Mechanisms of acute and chronic kidney injury and repair, including acute renal failure and studies of the pathobiology of acute kidney injury transition to chronic kidney disease and renal fibrosis as well as toxic nephropathy.
• Diabetic nephropathy and aging nephropathy. Podocyte biology and its role in the pathogenesis of chronic kidney diseases including diabetic nephropathy, nephrotic syndrome, and proteinuria.
• Renal tubular and glomerular pathophysiology, renal hemodynamics, and disease resulting from disorders of fluid, electrolyte and acid-base homeostasis.
• Disorders of tubular epithelial and endothelial cells and the pharmacology of associated kidney disease.
• Renal immunology and immune glomerular diseases including lupus nephritis and IgA nephropathy.
• Vascular biology of the kidney and the role of renovasculature in blood pressure regulation and in the development of hypertension. Mechanisms of hypertensive renal injury.

Shared Interests and Overlaps

There are shared interests with Kidney Physiology and Development [KUDS (82)] for studies involving renal physiology and transport mechanisms. Studies that focus on transport mechanisms or their regulation may be reviewed in KUDS (82), whereas those that focus on the pathophysiological consequences of aberrant transport may be reviewed in PBKD.

There are also shared interests with KUDS (82) with respect to renal hemodynamics, hypertension and salt handling. Studies focused on transport mechanisms and their regulation may be reviewed in KUDS (82), whereas those focused on hypertensive renal injury may be reviewed in PBKD.

There are shared interests with Integrative Vascular Physiology and Pathology (IVPP). Hypertension studies involving cardiovascular biology, microcirculation, lymphatic and central or the peripheral nervous system may be reviewed in IVPP, whereas studies involving hypertension-induced kidney injury may be reviewed in PBKD.

There are shared interests in kidney and urological conditions with Kidney, Endocrine and Digestive Disorders (KEDD). Applications that emphasize the determinants, predictors and biomarkers of kidney conditions in human subpopulations may be reviewed in KEDD, whereas applications that emphasize the pathophysiology and mechanisms underlying kidney conditions, including using animal models, may be reviewed in PBKD.