Small Business: Endocrinology, Diabetes, Metabolism, and Obesity – EMS (10)
The EMS Small Business standing SEP [EMS (10)] reviews SBIR/STTR applications in areas concerned with metabolism, diabetes and obesity. Endocrine regulation of steroid responsive tissues (mammary gland, ovaries, pancreas, prostate) is also included in this study section. Metabolic, molecular and neuroendocrine basis of energy expenditure and weight management, pathogenesis of obesity and diabetes and their management utilizing new and improved therapeutic strategies, bioengineering approaches in monitoring metabolic biomarkers are reviewed by EMS 10. In general, this study section covers sciences ranging across all EMS study sections including clinical trials, studies in mammalian, non-mammalian, and in vitro systems.
Review Dates
Topics
- Energy balance, expenditure, thermogenesis, physical activity, exercise and bariatric surgery in the context of the pathogenesis or treatment of obesity and diabetes
- Devices development and testingin clinical management/ treatment of metabolic and endocrine disorders and diabetic complications
- Diagnostic assay kits and automated assays for regulators of insulin synthesis.
- Biosensor (e.g., glucose sensors-chemical, optical and electrochemical etc.) to effect continuous glucose monitoring for effective treatment of diabetes; drug and nutrient delivery across cell and tissue systems.
- Differentiation, development, growth, and function of pancreatic islets, artificial pancreas. Beta cell viability and methods at optimization for use in islet transplantation and cell based therapies.
- Adipocyte functions, adiponectin secretagogues, inflammation and anti-inflammatory agents. Stem cell delivery for adipose tissue repair.
- Neuroendocrinology and pharmacological interventions in other endocrine disorders. Such as acromegaly, thyroid, and growth hormone disorders in adult and pediatric populations.
- Physiological, pathophysiological, molecular and cell biological processes involving hypothalamic, pituitary, pineal, thyroid, adrenal, gonadal, and pancreatic hormones. Invokes mammalian and non-mammalian systems, model organisms, and clinical studies
- Pathways focused on understanding steroid hormones and growth factors contribution to aging, normal growth regulation, menopause, and non-malignant pathologies development of endocrine responsive tissues e.g., ovaries, endometrium, mammary gland and prostate development.
- Nutrient, Nutraceuticals and dietary intervention in the treatment of these metabolic and endocrine disorders including diabetic complications and peripheral artery disease.
Shared Interests and Overlaps
There are shared interests with Kidney, Urology, Reproduction and Skin (KURS) Review Branch. Applications that focus on endocrine regulation of steroid responsive organs development and function including prostate gland development and differentiation up to benign prostatic hyperplasia may be reviewed by EMS 10, whereas those that focus on prostate hyperplasia effects on urinary tract may be reviewed in KURS.
There are shared interests with Bioengineering, Computation and Technology Development A, B & C Review Branches. Applications that focus on devices and technologies testing in clinical management and treatment of metabolic and endocrine disorders and diabetic complications may be reviewed by EMS 10, whereas those that focus on developing and applying emerging technologies may be reviewed by one of the Bioengineering, Computation and Technology Development Branches.
