HIV Comorbidities and Clinical Studies Study Section – HCCS
The HIV Comorbidities and Clinical Studies (HCCS) study section reviews applications related to the effects of chronic HIV infection and/or antiretroviral drug therapy on end organ diseases. Studies include basic science studies, animal models, and clinical studies. Examples of end organ disease commonly seen includes cardiomyopathy, renal disease, liver disease, pulmonary dysfunction, neurocognitive and neurological disorders, metabolic complications, and diabetes. The study section also reviews applications involving clinical studies of HIV and aging, clinical management of symptoms and disease progression in children, pregnant women, adults and other defined cohorts.
This study section operates on an expedited cycle as mandated by Congress and only applications in which there is a clear and compelling HIV/AIDS research component are eligible for review in HCCS. Those deemed insufficiently related to HIV/AIDS are assigned to other non-expedited study sections and must be submitted in time to meet the regular application due dates.
Review Dates
Topics
- The mechanisms involved in CNS dysfunction, neuroimaging, neurological and neurocognitive studies
- The biological effects of drug abuse on the CNS and other organs in the context of HIV/AIDS
- Basic, clinical, and epidemiological studies of cardiovascular, pulmonary, hematologic, metabolic, digestive diseases and sleep comorbidities as a consequence of HIV infection and/or anti-retroviral treatment
- Studies of risk factors and/or biomarkers for HIV associated comorbidities
- Basic and clinical studies (with biological outcomes) of the effect of HIV on aging and interactions of the aging processes on HIV progression and comorbidities
- The clinical management of symptoms and disease associated with HIV infection in defined cohorts
- Clinical studies on the biological effects and efficacy of pre- and post-exposure prophylaxis in adults, including pregnant women, and children
- Clinical studies addressing inflammation and its contribution to organ disease in HIV infection and antiretroviral therapy
- Non-immunological clinical studies to characterize organ-based viral reservoirs and interventions to eliminate them
- Clinical studies on antiretroviral drug side effects and drug resistance including pharmacogenetics
Shared Interests and Overlaps (HIV/AIDS):
There are shared interest with Population and Public Health Approaches to HIV/AIDS (PPAH). Epidemiological studies employing behavioral measures and/or behavioral outcomes may be reviewed in PPAH, whereas epidemiological studies employing biological assays and/or focusing on biological outcomes may be reviewed here.
There are shared interests with HIV Molecular Virology, Cell Biology, and Drug Development (HVCD). Basic biological studies employing cell culture and animal models may be reviewed in HVCD, while clinical studies that address biological effects of drug abuse, approaches to characterize and eliminate viral reservoirs, drug resistance and side effects of antiretroviral drugs may be reviewed here.
There are shared interests with HIV Immunopathogenesis and Vaccine Development (HIVD). Studies addressing immune mechanisms of virus clearance and pathogenesis may be reviewed in HIVD, whereas clinical studies that address inflammation and its contribution to HIV-related organ disease, viral reservoirs and interventions to eliminate them, and non-immunological effects of drug abuse on the CNS and other organs in the context of HIV/AIDS may be reviewed here.
There are shared interests with HIV Coinfections and HIV Associated Cancers (HCAC). Clinical studies related to HIV coinfections and/or HIV associated cancers and certain basic biological studies of HIV associated organ diseases employing animal and cell culture models may be reviewed in HCAC, while studies that address clinical aspects of HIV associated organ diseases may be reviewed here.
Shared Interest and Overlaps (non-HIV/AIDS)
The Clinical Neuroimmunology and Brain Tumors (CNBT) study section includes studies of CNS infectious diseases and associated pathologies.
The Clinical and Integrative Cardiovascular Sciences (CICS) study section reviews clinical research involving the cardiovascular system and related regulatory organ systems.
