Bacterial Innate Immunomodulation and Pathogenesis – IIDB (81)
The Bacterial Innate Immunomodulation and Pathogenesis [IIDB (81)] study section reviews grant applications focused on the innate mechanisms of immunopathogenesis in bacterial infections, the modulation of innate immune responses by bacteria, and the development and use of alternative infection models to study these processes. This includes understanding how bacterial pathogens evade or manipulate the host's innate immune system, exploring novel therapeutic targets, and developing and improving model systems to better simulate human innate immune responses.
Review Dates
Topics
- Mechanistic studies on how bacterial pathogens manipulate host innate responses that contribute to disease pathogenesis at the molecular, cellular, and systemic levels.
- Research on how bacterial pathogens modulate innate immune responses to establish infection.
- Investigation of the role of immunomodulatory factors produced by bacteria that inhibit or manipulate innate immune signaling pathways.
- Development and utilization of novel in vitro, ex vivo, and in vivo models to study innate immunity against bacterial infections.
- Use of non-mammalian animal models, organoids, microfluidic systems, and other advanced technologies to mimic human innate immune responses to bacterial infection.
Shared Interests and Overlaps
There are shared interests with Bacterial-Host Interactions (BHI) in the investigation of bacteria and bacterial factors that alter/affect host cells, or the host aspect of the host-pathogen interaction including host defense strategies. Applications focused on bacterial factors that alter/affect host cells, or the integrated host responses due to host-bacterium interaction may be reviewed in BHI. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDB (81).
There are shared interests with Immunity and Host Defense (IHD), which reviews applications that focus primarily on the host innate and adaptive immune defensive responses to a wide variety of infectious disease microbes and microbiome communities, including viruses (except HIV), bacteria, fungi, and parasites. Studies focused on immune system defenses and development of immunity to microbial infection with a strong focus on the host may be reviewed by IHD. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDB (81).
There are shared interests with Bacterial Virulence (BV) in the investigation of regulation and determinants of bacterial virulence and pathogenicity and the bacterial side of host-pathogen interactions. Applications that focus on addressing determinants of bacterial virulence and pathogenicity from the perspective of the bacteria may be reviewed in BV. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDB (81).
There are shared interests with Innate Immunity A [ZRG IIDA (81)] and Innate Immunity B (IIB) study sections. Applications with an emphasis on cell-based studies of the innate immune system and its regulation may be reviewed in IIDA (81), whereas those applications involving fundamental aspects of innate immunity, with an emphasis on the integrated innate immune and inflammatory response to infection or injury may be reviewed by IIB. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDB (81).
