Cardiovascular Differentiation and Development SEP – ZRG1 CDD 81
The Cardiovascular Differentiation and Development (ZRG1 CDD 81) Special Emphasis Panel (SEP) reviews basic research applications related to development and differentiation of cardiovascular systems that include heart, vascular and lymphatics. Experimental approaches and technologies typically include, but are not limited to cellular, molecular, genetic, genomic/proteomic and use of transgenic models.
Studies utilize varied experimental model systems including mouse, chick, zebrafish, xenopus and drosophila, among others. ZRG1 CDD 81 reviews molecular and genetic studies of human cells and tissues as well as the evaluation of bioengineered cells and tissues in the context of cardiac, vascular or lymphatic systems.
Review Dates
Topics
- Cardiac development, including: commitment and differentiation of cardiac cell phenotypes; looping morphogenesis; cardiac chamber specification, valvulogenesis; epicardial and coronary vessel development; neural crest in developing heart and great vessels; cardiac conduction system; embryonic cell processes, cellular signaling and transcriptional regulation in heart development, structural or mechanical controls of cardiac development, normal developmental cardiac hypertrophy
- Vascular development, including: origin, commitment and differentiation of endothelial and smooth muscle cell populations; vasculogenesis and angiogenesis; patterning and organization of the vascular system; vascular remodeling in the postnatal organism; neovascularization in adults recapitulating embryonic and fetal processes.
- Lymphatic development including: differentiation, development and organization of the lymphatic vascular system; molecular and cellular mechanisms of lymphangiogenesis; lymphedema; structural and mechanical influences on lymphangiogenesis
- Stem cells: differentiation of embryonic and adult stem cells into cardiomyocytes, endothelium, smooth muscle and other components of the cardiovascular system; resident stem cells in regeneration and repair of myocardium and vasculature in vivo
- Human genetics of cardiac and vascular malformations; studies related to human congenital defects of cardiovascular system; modeling of human developmental cardiovascular diseases in different organisms.
- Evaluation of bioengineered tissue in the context of developing, differentiating or regenerating cardiac, vascular or lymphatic systems
Shared Interests and Overlaps
There are shared interests between the CDD Special Emphasis Panel (SEP) and Integrative Vascular Physiology and Pathology (IVPP). Studies which focus on developmental aspects of vascular/lymphatic growth may be reviewed in the CDD SEP, however applications which investigate pathological aspects of vascular changes may be reviewed in Integrative Vascular Physiology and Pathology (IVPP).
There are shared interests between CDD SEP and Development-1 (DEV1). Studies which focus on cardiac, vascular and lymphatic development may be reviewed in the CDD SEP where applications investigating more general organ system development may be reviewed in Development-1 (DEV1).
There are shared interests between CDD SEP and Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB. Studies which focus on the differentiation potential of stem cells, including naturally occurring developmental hypertrophy, even postnatally, may be reviewed in the CDD SEP. Applications which investigate disease-induced cardiomyocyte hypertrophy may be reviewed in Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB.
There are shared interests between CDD SEP and Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB. Studies which focus on
the fate of stem cells in terms of differentiation potential, may be reviewed in the CDD SEP. Applications which investigate the ability of stem cells to correct tissue damage after a cardiac event may be reviewed in Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB.
There are shared interests between the CDD SEP and Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB. Studies which focus on developmental and genetic aspects of cardiac cells, those that promote cardiac conduction, may be reviewed in the CDD SEP. Applications which investigate the physiology of cardiac conductions may be reviewed Integrative Myocardial Physiology/Pathophysiology A (MPPA) / MPPB.
There are shared interests between the CDD SEP and bioengineering-related study sections, including Biomaterials and Biointerfaces Study Section (BMBI) and Bioengineering, Technology, and Surgical Sciences (BTSS). Studies which focus on evaluating the bioengineered cells and tissues in the context of cardiac, vascular and lymphatic differentiation & development may be reviewed in the CDD SEP; applications may include a focus on the differentiation of the cell into a cardiac myocyte, in vivo and in vitro.
