Integrative Vascular Physiology and Pathology – IVPP
The IVPP study section reviews applications focused on endothelial cells, blood vessels and lymphatics and their role in normal physiology and disease. Cellular, biochemical, biophysical, immunological, genetic, pharmacological, and molecular biological approaches are typical. Basic and applied aspects of cardiovascular regulation are reviewed that focus on the physiology of blood pressure regulation, the pathogenesis of hypertension and the microcirculation, biology of the endothelium and vascular smooth muscle cells and vascular homeostasis and dysfunction in experimental models. Studies on cell surface receptors and signaling processes of various hormones, paracrines, and autocrines and their mechanisms of action as related to hypertension, integrated neural-humoral control of circulation, regional hemodynamics, lymphatic circulation, and microcirculation are also considered.
Review Dates
Topics
- Vascular cell and molecular biology of blood vessels ranging from major arteries to the microcirculation and sex-specific microvascular disease mechanisms.
- Neural and humoral control of the cardiovascular system in vertebrate animals including systems analysis of autonomic physiology involving central and peripheral mechanisms of cardiovascular regulation.
- Mechanisms that regulate vascular angiogenesis and rarefaction, cardiovascular stem cell functions and senescence.
- Hypertension (excluding pulmonary hypertension). Mechanisms that regulate arterial blood pressure, role of kidneys and other tissues/organs, nervous and endocrine systems, autocrine, paracrine factors. Pathogenesis of systemic hypertension.
- Vascular pathology in hypertension and co-morbidities, metabolic syndrome, chronic degenerative diseases (e.g. Alzheimer, retinopathy), stroke, cardiac microvascular dysfunctions, and aging.
- Vascular inflammation, immune regulation and dysregulation.
- Microcirculation and tissue transport processes, lymphatics, autonomic regulation. Capillary/vascular dynamics, mechanics and permeability, cellular and fluid mechanics and mechanotransduction.
- Vascular responses and changes due to environmental exposure, stress, metabolic disorders, aging and vascular drug toxicity.
- Pathogenesis of microvascular diseases related to diabetic vasculopathy, stroke, ischemia/reperfusion and chronic microvascular diseases such as Raynaud’s disease. Propulsion of lymph, lymphatic tone, and pathogenesis of lymphedema.
- Mediators and modulators of vascular smooth muscle contractility: calcium homeostasis; calcium sensitive proteins; neural, redox, and transcriptional regulation of genes and proteins that modulate vascular excitability and contractility; regulation of ion channel function and expression.
- Injury/repair; remodeling; angioplasty; restenosis; grafts; stents; re-endothelialization; neointima hyperplasia; spasm; varicose; embolism; fistula; edema; stem cells.
Shared Interests and Overlaps
IVPP and Atherosclerosis and Vascular Inflammation (AVI) have shared interests in addressing vascular inflammation and vascular responses due to environmental and physiological changes. Applications that emphasize atherosclerosis, addressing the role of hemodynamics in atherosclerotic plaque formation and rupture and in aneurysm formation and rupture will be assigned to AVI. Applications that emphasize blood flow and circulation will be assigned to IVPP.
IVPP and Integrative Myocardial Physiology/Pathophysiology A (MPPA) have shared interests in the area of cardiac contractility and vascular smooth muscle contractility. Applications that emphasize the application of these in humans will be assigned to MPPA. Applications that emphasize the application of these in cells and tissues will be reviewed in IVPP.
IVPP and Integrative Myocardial Physiology/Pathophysiology B (MPPB) have shared interests in the area of hypertension. Applications that emphasize hypertension in humans will be reviewed in MPPB. Applications that emphasize hypertension in the context of cells and tissues will be reviewed in IVPP.
IVPP and Clinical Integrative Cardiovascular and Hematological Sciences (CCHS) have shared interests in topics related to blood pressure regulation, hypertension, neural control of the cardiovascular system, and micro- or regional circulation. Applications that emphasize the clinical aspects of these topic areas in humans and human samples will be reviewed in CCHS. Applications that focus on the basic and translational aspects of these topic areas, typically in animal models, will be reviewed in IVPP.
IVPP and Pathobiology of Kidney Disease (PBKD) have shared interests in hypertension. Applications that emphasize studies involving hypertension-induced kidney injury will be reviewed in PBKD. Applications that emphasize hypertension studies involving cardiovascular biology, microcirculation, lymphatic and central or peripheral nervous system will be reviewed in IVPP.
IVPP and Brain Injury and Neurovascular Pathologies (BINP) have shared interests in neural injury and vasculature. Applications that emphasize blood-brain barrier and vascular functions in development and treatment of neural injury and stroke will be reviewed by BINP, for animal studies, and ANIE, for human subject studies. Applications that emphasize stroke, microcirculation and flow related to hypertension will be reviewed by IVPP.
IVPP and Cardiovascular Differentiation and Development (CDD) have shared interests in lymphatic systems. Applications that emphasize lymphatic development, lymphangiogenesis and lymphedema focusing on structure will be reviewed in CDD. Applications that emphasize lymphatic function, lymphatic tone, and pathogenesis of lymphedema will be reviewed in IVPP.
IVPP and Therapeutic Development and Preclinical Studies (TDPS) have shared interests in the mechanisms of action, identifying potential therapeutic targets and/or delivering therapeutic agents aimed at treating disorders such as hypertension and vascular stiffness. Applications that emphasize characterization mechanisms of action towards identifying potential therapeutic targets and/or delivering therapeutic agents in preclinical models will be reviewed in TDPS. Applications that emphasize mechanisms of action of disorders, hypertension and vascular stiffness will be reviewed in IVPP.
IVPP and Bioengineering, Technology and Surgical Sciences Study Section (BTSS) have shared interests in the areas of cardiovascular regulation. Applications which focus on microcirculatory biophysics and bioengineering including mechanotransduction, fluid dynamics and mechanics, computational modeling and engineering, and structural adaptation and remodeling of the vascular system in hypertension and blood pressure regulation are appropriate for IVPP. Applications which focus on cardiovascular surgery are assigned to BTSS.
