The Lung Cellular, Molecular and Immunobiology (LCMI) study section reviews grant applications designed to investigate the genetic, molecular, and cellular basis of normal respiratory biology, including lesions in these processes which result in inflammatory and immune-related lung disorders. LCMI will consider applications using molecules, cells, tissues, organs, animal models, and/or human subjects that aim to address the identity, function, and products associated with cells which populate the airways, this includes the regulation and dysregulation of innate host defense mechanisms and the adaptive immune system in health and disease as they relate to the respiratory system. Topics may include inflammatory and/or immune mechanisms which contribute to the pathogenesis of a variety of airway diseases, including, but not limited to, Asthma, Cystic Fibrosis, Chronic Obstructive Pulmonary Disease (COPD) and Tuberculosis.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Inflammatory disease of the airways of the lungs, including Asthma: molecular and cellular mechanisms, pathology and remodeling of airway epithelial cells and airway smooth muscle; cytokine transport and regulation; effects of oxidant and leukotriene products on the airways; T cell secretions and regulation; adrenergic agonists and receptors; genetic predisposition.
- Cystic Fibrosis, with a focus on lungs: molecular mechanisms Cystic Fibrosis Transmembrane Conductance Regulator in airway epithelial cells; bacterial interactions with airways in Cystic Fibrosis.
- Airway Epithelial Cell Biology: regulation of secretion of mucins, control of cilia, and development of goblet cell metaplasia.
- Host Defense of the lung: pulmonary interactions and reactions to pathogens including aspergillus, influenza, pseudomonas, tuberculosis, rhinovirus, Respiratory Syncytial Virus and other lung pathogens; mechanisms associated with pneumonia, tuberculosis; mechanisms of surfactant proteins in lung host defense.
- Immunology of the lung, including: biology, regulation and interactions of alveolar macrophages, T lymphocytes, neutrophils, eosinophils, dendritic cells, mast cells, and B lymphocytes; immunological effects of lung transplantation.
- Chronic Obstructive Pulmonary Disease (COPD), including: the effects of smoking on airway epithelia cells, airway epithelia cell remodeling in chronic bronchitis.
Shared Interests and Overlaps
There are shared interests between LCMI and Immunity and Host Defense (IHD) . While both study sections review applications focused on innate and adaptive immune responses to a wide variety of pathogens, LCMI reviews such applications that involve the respiratory system.
There are shared interests between LCMI and Innate Immunity and Inflammation (III) . While both study sections review applications which investigate basic aspects of innate immunity and inflammation associated with infectious diseases, LCMI will review applications that involve these topics as they relate to the respiratory system.
There are shared interests between LCMI and Bacterial-Host Interactions (BHI). While both study sections review applications that focus on host immune responses to bacteria, those that involve bacterial infections in the context of airway diseases may be reviewed by LCMI while those that focus on general immune responses against bacteria may be reviewed by BHI.
There are shared interests between LCMI and Hypersensitivity, Autoimmune, and Immune-mediated (HAI) . Though both study sections review applications which focus on asthma and the immune responses which determine asthma, LCMI will review applications that involve aspects airway conditions which include airway hyperresponsiveness, airway remodeling and airway cell biology.
There are shared interests between LCMI and Lung Injury, Repair, and Remodeling (LIRR) . Though both study sections review applications involving studies of inflammation of non-vascular lung tissue, LCMI is focused on the airways while LIRR is more focused on alveolar and mesenchymal tissue.
There are shared interests between LCMI and Respiratory Integrative Biology and Translational Research (RIBT) . Though both study sections review applications involving studies that focus on the respiratory system, LCMI is more focused on diseases in the airways, while RIBT reviews studies of more integrated pulmonary responses such as neural control of breathing, clinical studies of lung disease, and physiologic aspects of the lung. Applications which focus on pulmonary vascular disorders are more appropriately reviewed in RIBT.
here are shared interests between LCMI and Bacterial-Host Interactions (BHI) and Bacterial Virulence (BV) study sections. While all 3 study sections review applications focused on immune responses to bacterial infection, host responses in the context of lung and airway diseases may be reviewed in LCMI. Also, applications focused on molecular mechanistic models of bacterial infection or pathogenesis and immunity emphasizing the bacterial perspective may be reviewed in BV or BHI.