The Pulmonary Vascular Disease and Physiology (PVP) study section reviews integrative research involving pulmonary vascular biology and disease, respiratory biophysics and biomechanics, neural control of breathing, and upper airway physiology. Methods may include molecular and cellular approaches, normal and genetically modified animal models, human subjects, and mathematical modeling. Emphasis is on physiologic, integrative, and translational approaches, including combining model simulations with experiments, interactions between and across tissues and cell types, and hierarchical approaches that link micro- and macro-level responses.

Review Dates


  • Pulmonary vascular biology, including angiogenesis, normal and abnormal endothelial and vascular smooth muscle cell biology, and mechanisms of vasoreactivity, barrier function of the vascular cells in relation to lung fluid balance.
  • Pulmonary vascular disease, including pulmonary hypertension, lung injury when the focus is on vascular function, and the involvement of reactive oxygen and nitrogen species as well as hypoxia in these processes. 
  • Respiratory biophysics, biomechanics, and imaging of the lung and chest wall, including mechanical ventilation, application of imaging techniques, aerosol inhalation, gas transport, disordered breathing and obstructive sleep apnea.

Shared Interests and Overlaps

There are shared interests with Pulmonary Injury, Repair, and Remodeling (PIRR). Applications involving the study of cellular and molecular mechanisms of lung injury and repair may be reviewed in PIRR, whereas applications focused on respiratory physiology, genetics, biophysics, biomechanics, and imaging of the lung may be reviewed in PVP

There are shared interests with Lung Immunology and Infection (LII). Applications focused on host inflammatory responses associated with lung function may be reviewed in LII, whereas applications focused on pulmonary vascular disorders may be reviewed in PVP.

There are shared interests with Translational Investigations of Pulmonary and Immunological Diseases (RCCS (81)). While PVP will evaluate basic or physiological topics related to vascular conditions and diseases, studies which are patient-oriented and/or include clinical trials may be reviewed in RCCS (81).

There are shared interests with Integrative Myocardial Physiology/Pathophysiology A (MPPA). Studies of pulmonary conditions which focus on models of right ventricular heart failure may be reviewed in MPPA, whereas applications which generally focus on pulmonary conditions, including pulmonary hypertension, may be reviewed in PVP.


Last updated: 05/13/2024 12:38