Chronic Dysfunction and Integrative Neurodegeneration Study Section – CDIN
Dr. Bernard Srambical Wilfred
Scientific Review Officer
The Chronic Dysfunction and Integrative Neurodegeneration (CDIN) Study Section reviews applications to investigate the etiology and pathogenesis of neurodegenerative disorders. Applications typically propose pre-clinical, integrated physiological studies of neurodegeneration, and integrated endpoints as a consequence of cellular disturbances using molecular and vertebrate animal model experimental approaches. Most neurodegenerative disorders are covered, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementias, spinal muscular atrophy, acquired dystonias and ataxias. Also included are prion diseases and vascular contributions to cognitive impairment and dementia (VCID). Applications may also explore therapeutic strategies using integrated experimental approaches in vivo.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
Review Dates
Topics
- Functional and physiological consequences of:
- neurotoxic insults in neurodegenerative diseases.
- impaired protein maintenance (e.g., beta amyloid, tau, alpha-synuclein, TDP-43).
- metabolic abnormalities and the interaction of genetics, epigenetics, environment, drugs, mitochondrial physiology and age on neuronal dysfunction and neurodegenerative diseases.
- neurodegenerative states on behavior and cognition.
- Generation and characterization of genetically modified or induced animal models of neurodegenerative diseases.
- Pre-clinical assessment of therapeutics strategies using integrated physiological and cellular/molecular approaches.
Shared Interests and Overlaps
There are shared interests in cognitive dysfunctions in neurodegenerative disorders with Cognitive Disorders and Brain Aging (CDBA). Applications that emphasize preclinical studies on neurodegenerative disorders are reviewed in CDIN. Applications that emphasize animal studies on delirium and cognitive behavioral outcomes in humans are reviewed in CDBA.
There are shared interests in the pathophysiology of neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis with Clinical Neuroimmunology and Brain Tumors (CNBT), and the Clinical Neurodegeneration Translational Neuroscience (CNTN). Applications that emphasize using molecular and vertebrate animal model experimental approaches primarily focused on the pathogenesis, mechanisms, structural and functional alteration, as well as the treatment of different CNS degenerative diseases are reviewed in CDIN. Applications that emphasize the neuroimmunology and neuroinflammation in these CNS degenerative diseases, rather than the diseases themselves or are focused on neuroimmune cells and pathways in these diseases are reviewed in CNBT. Applications that emphasize addressing the etiology, pathophysiology, diagnosis, and progression of these disorders and/or their functional consequences and the mechanisms and management of human chronic neurodegenerative diseases are reviewed in CNTN.
Cellular and Molecular Biology of Neurodegeneration (CMND) typically reviews applications with a significant focus on cellular and molecular aspects of neurodegeneration to primarily address mechanistic questions whereas application with a primary focus on pre-clinical, integrated cellular/molecular and physiological aspects of neurodegeneration are reviewed by CDIN.
Clinical Neuroplasticity and Neurotransmitters (CNNT) reviews in vitro and brain circuitry studies from animal models for Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and dystonia.
Brain Injury and Neurovascular Pathologies (BINP) reviews applications primarily focused on the mechanisms for the vascular components involved in VCID, whereas CDIN reviews applications with significant emphasis on the dementia or cognitive issues in VCID in the pre-clinical models.
Neural Oxidative Metabolism and Death (NOMD) reviews applications with an emphasis on basic mechanisms of cell death, neuroprotection, and neuronal mitochondrial biology in the context of neurodegeneration.
