Therapeutic Approaches to Genetic Diseases Study Section – TAG
TAG study section covers mechanisms by which genome abnormalities that cause rare genetic disease lead to disease pathogenesis. Further, the study section covers development of therapeutics for all genetic diseases.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
Review Dates
Topics
- Molecular and cellular mechanisms of genetic disease pathogenesis at the level of: gene expression; epigenetic modifications; RNA metabolism; protein structure function; protein synthesis, post-translational modifications, folding and trafficking; metabolic and signaling pathways; regulatory networks.
- Development of genetic disease therapies: cellular and gene therapies; transfer, replacement and correction of genes; changes of gene expression through silencing or activation, e.g., by targeted recruitment of transcription activators/ repressors/ epigenomic modifiers; interventions (including small molecules) altering protein function, e.g., folding or post-translational modifications, enzyme replacement and substrate reduction therapies.
- Development of resources for mechanisms and therapies of genetic diseases: stem cells, nucleic acid transfer vectors, and animal models of human diseases.
- Preclinical and initial clinical studies of genetic disease therapies.
Shared Interests and Overlaps
There are shared interests in rare genetic disease with Genetics of Health and Disease (GHD). Applications that emphasize molecular mechanisms of genetic disease pathogenesis or focused on development of therapies are reviewed in TAG. Applications that emphasize mendelian gene discovery with complex genetic or genomic methods are reviewed in GHD.
Molecular Neurogenetics (MNG) Applications focused on the neuroscience context of rare diseases may be reviewed by MNG; studies focused on molecular mechanisms of pathogenesis of rare diseases with neurological pathology may be reviewed by TAG.
Other neuroscience study sections may review applications focused on molecular neurology of rare diseases; applications focused on the molecular mechanisms of neurological pathogenesis and therapies for rare disease may be reviewed by TAG.
Other organ disease focused study sections may review applications studying pathogenesis and treatments for rare diseases related to their respective organ; TAG reviews applications focused on molecular pathogenesis and therapies of rare diseases as multi-organ diseases.
