Bacterial Innate Immunomodulation and Pathogenesis – IIDC (81)

Topics

• Mechanistic studies on how bacterial pathogens manipulate host innate responses that contribute to infections or infection-related disease pathogenesis at the molecular, cellular, and systemic levels.
• Research on how bacterial pathogens or bacterial communities modulate innate immune responses and influence outcomes of infection-related or dysbiosis-related diseases.
• Investigation of the role of immunomodulatory factors produced by bacteria that inhibit or manipulate innate immune signaling pathways and downstream responses.
• Studies focused on host co-morbidities, therapeutics/interventions, or prior microbial exposures that alter the interplay of the innate immune system with bacterial pathogens or microbiome communities to impact disease pathogenesis.
• Development and utilization of novel in vitro, ex vivo, and in vivo models to study bacterial induced innate immunopathogenesis
• Use of non-mammalian animal models, organoids, microfluidic systems, and other advanced technologies to mimic human innate immune responses.

Shared Interests and Overlaps

There are shared interests with Bacterial-Host Interactions (BHI) in the investigation of bacteria and bacterial factors that alter/affect host cells, or the host aspect of the host-pathogen interaction including host defense strategies. Applications focused on bacterial factors that alter/affect host cells, or the integrated host responses due to host-bacterium interaction may be reviewed in BHI. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDC (81).

There are shared interests with Immunity and Host Defense (IHD), which reviews applications that focus primarily on the host innate and adaptive immune defensive responses to a wide variety of infectious disease microbes and microbiome communities, including viruses (except HIV), bacteria, fungi, and parasites. Studies focused on immune system defenses and development of immunity to microbial infection with a strong focus on the host may be reviewed by IHD. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDC (81).

There are shared interests with Bacterial Virulence (BV) in the investigation of regulation and determinants of bacterial virulence and pathogenicity and the bacterial side of host-pathogen interactions. Applications that focus on addressing determinants of bacterial virulence and pathogenicity from the perspective of the bacteria may be reviewed in BV. Studies focused on bacterial modulation of innate immune responses and innate disease pathogenesis in bacterial infections may be reviewed by IIDC (81).

There are shared interests with Innate Immunity B (IIB) in innate responses to bacterial infection. Applications that focus on the integrated innate immune and inflammatory responses to infection or injury with a strong focus on the host regardless of stimuli may be reviewed by IIB. Studies focused on bacterial modulation of innate immune responses and how the innate response contributes to infection-related disease pathogenesis may be reviewed by IIDC (81). 

There are shared interests with Interspecies Microbial Interactions and Infections (IMII) in mechanisms of host-pathogen interactions in bacterial infections. Applications emphasizing the interspecies interactions of bacterial pathogens with other microbes or within microbial communities during host-pathogen interactions may be reviewed by IMII. Studies focused on bacterial or microbiome modulation of innate immune responses and how the innate response contributes to infection-related disease pathogenesis may be reviewed by IIDC (81).

There are shared interests with Lung Immunology and Infection (LII) in innate host responses to pulmonary bacterial pathogens or lung microbiome communities. Applications with a strong focus on integrated pulmonary responses and pathological consequences in the lung to any microbial pathogen or microbial community are reviewed in LII. Studies focused on bacterial modulation of innate immune responses and how the innate response contributes to infection-related disease pathogenesis regardless of host niche may be reviewed by IIDC (81).

There are shared interests with Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases (EDIT) and Population-based Research in Infectious Disease (PRID) in the general area of bacterial infections in human populations. Applications that focus on translational and applied studies examining epidemiology, therapeutics, prophylactics, or diagnostics of bacterial infections may be reviewed in EDIT. Applications that focus on population-based research that characterize the incidence, transmission, and prevention of infectious diseases regardless of pathogen may be reviewed in PRID. Applications that focus on mechanistic in vitro studies and animal models of bacterial diseases may be reviewed in one of the bacterial-focused study sections BV, or BHI, or IIDC (81). 

There are shared interests with Drug Discovery and Molecular Pharmacology A (DMPA) in investigating efficacy or impact of therapeutics during host-bacterial interactions at the level of the innate response.  Applications that focus on identifying novel drug targets or emphasize developing new antimicrobial drugs may be reviewed in DMPA. Applications focused on targeting bacterial factors that alter/affect innate host cells or the host innate responses due to host-bacterium interaction during therapeutic intervention may be reviewed in BHI or IIDC (81). 

There are shared interests in vaccine development with Vaccines Against Infectious Diseases (VID) in the interplay of innate processes and memory immunity to bacterial infections. Applications that emphasize measurement of vaccine efficacy as the endpoint may be reviewed in VID. Applications that emphasize early- and mid-stages of vaccine development, or aim to characterize vaccine-induced immune responses may be reviewed in DCAI (89). Studies focused on direct bacterial modulation of innate immune responses and how the innate response contributes to infection-related disease pathogenesis may be reviewed by IIDC (81).