R21 Basic Cancer Mechanism and Therapeutics – BCMT (81)
The special emphasis panel focuses on applications investigating tumor progression and therapeutic mechanisms. Specifically, basic mechanisms of interactions between tumor and host system; mechanisms of tumor progression and metastasis; mechanisms-of-action of emerging therapeutics; and molecular identification and functional validation of novel molecular targets.
Review Dates
A roster for the panel will be posted here, at least 30 days prior to the review meeting
Topics
- Tumor progression, metastasis, angiogenesis, tumor cell adhesion, invasion/migration, dormancy and tumor dissemination
- Molecular and cellular aspects of tumor cell heterogeneity, plasticity and epithelial-mesenchymal transitions (EMT)as they relate to tumor invasion and metastasis.
- Mechanisms of tumor dormancy and recurrence.
- Immune signaling pathways and deregulation in the tumor microenvironment (immune suppression, immune tolerance, immune surveillance, immune evasion)
- Mechanisms-of-action of emerging therapeutics at molecular, cellular, and organism levels including mechanistic validation of and functional evaluation of novel molecular targets, including multidisciplinary studies that span biochemical, structural, cellular, and in vivo characterizations
