HVCD reviews basic studies involving molecular virology of HIV and host factors impacting viral transmission, replication, expression and persistence in all target cells/tissue susceptible to HIV infection. It also reviews applications involving non-immunological therapeutics and prophylaxis, the identification of potential drug targets, mechanisms of drug action and viral drug resistance and gene-based therapies for HIV.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Structure and function of viral gene products and host factors in virus replication, expression and infection.
- Mechanisms of viral evolution and fitness.
- Viral and host genetic factors that impact susceptibility to HIV in all target cells/tissues.
- System wide approaches including metabolomics, transcriptomics, and phenomics.
- Molecular mechanisms of the cellular establishment of latency and viral reactivation, and strategies to eliminate latent/persistent reservoirs.
- Identification of novel drug targets to disrupt HIV activities and/or host-virus interactions.
- Preclinical drug development for HIV/AIDS prevention and therapy including in vitro and in vivo assessments of efficacy, pharmacology, and toxicity.
- Preclinical development of gene and/or nucleic acid targeting strategies.
- Preclinical development of antiretroviral drugs, including long-acting formulations, nanotechnology, targeted drug delivery and multipurpose prevention technologies
- Structural and computational approaches to drug and vaccine design.
Shared Interests and Overlaps
HIV Immunopathogenesis and Vaccine Development (HIVD): Structural, molecular, and non-immunological studies on HIV infection, pathogenesis, persistence, and therapeutics, including the targeting and elimination of HIV reservoirs, are reviewed in HVCD. Studies addressing immunological aspects of HIV infection, pathogenesis and persistence, immune responses and dysfunction, immune therapeutic approaches, and the development and delivery of candidate HIV vaccines are assigned to HIVD.
HIV Comorbidities and Clinical Studies Study Section (HCCS): Basic biological, biochemical and molecular studies addressing preclinical antiretroviral drug development, mechanisms of drug resistance, and the effects of abused drugs on HIV biology and antiretroviral therapies may be assigned to HVCD. HVCD also reviews molecular biology research addressing HIV-associated end organ diseases. Clinical studies addressing HIV-associated end organ diseases, biological effects of drug abuse (in the context of HIV/AIDS), antiretroviral drug resistance, or side effects of antiretroviral drugs are reviewed in HCCS.
HIV Coinfections and HIV Associated Cancers (HCAC): Applications that address preclinical development of antiretroviral drugs are reviewed in HVCD; studies on the development of drugs and immune therapeutic strategies to target AIDS-associated opportunistic pathogens may be reviewed in HCAC, if there is a clear and compelling HIV/AIDS context.
Only applications in which there is a clear and compelling HIV/AIDS research component in the proposed research plan are eligible for the AIDS deadlines and review in HVCD and other AARR study sections. Those deemed insufficiently related to HIV/AIDS are assigned to other study sections and must be submitted in time to meet the regular non-AIDS application due dates. Applicants might consider requesting study sections in the following study sections:
Virology A Study Section (VIRA): VIRA reviews applications addressing fundamental aspects of non-HIV viral infection, replication and pathogenesis with a focus on the biophysical aspects of virology including structural biology.
Gene and Drug Delivery Systems Study Section (GDD): The GDD study section reviews applications on fundamental aspects of gene and drug delivery, including delivery vehicle development, targeting strategies, and biological barriers.
Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section (DDR): The DDR study section reviews applications on the identification of novel antibacterial, antiparasitic, antifungal and antiviral agents for the prevention and treatment of infectious diseases and the study of the evolution, mechanisms, and transmission of drug resistance.