The F09A panel reviews fellowship applications dealing with a subset of scientific disciplines covered by the Oncology – Basic Translational (OBT) integrated review group including cancer etiology, oncogenesis, and cancer genetics and genomics.
- Cancer etiology including environmental carcinogenesis, non-HIV viral carcinogenesis, oxidative stress, reactive oxygen species (ROS) and DNA damage/repair
- Characterization of putative oncogenes, tumor suppressor genes, and signal transduction pathways in oncogenesis
- Gene regulation and expression in oncogenesis, including chromatin structure and remodeling, transcription, RNA processing and stability, non-coding RNAs and translation
- Cancer genetics, epigenetics, genomics, and proteomics, including studies of genomic and proteomic instability
- Identification and characterization of oncogenic progenitor or stem cells
- Mechanisms of cell death pathways in tumor growth or suppression
- Tumor metabolism and molecular mechanisms of cell cycle regulation
Shared Interests and Overlaps
Fellowship panels are broad and cover inter-related areas. Assignments are made based on the primary emphasis of the proposed research and topics in several fellowship panels overlap as described below. Final assignments are made by the staff at the Center for Scientific Review to ensure that each application has the appropriate expertise to review it.
There are shared interests with the Oncological Sciences B (F09B) fellowship panel in tumor metastasis and progression and tumor cell biology. Applications that focus on tumor cell signaling and basic mechanisms of tumor metastasis may be assigned to F09A. Applications that focus on tumor cell signaling and metabolism as it relates to therapeutic mechanisms and tumor metastasis with an emphasis on tumor microenvironment may be assigned to F09B.
There are shared interests with the Macromolecular Structure and Function B (F04B) fellowship panel in signal transduction and macromolecular interactions. Applications that focus on signal transduction and macromolecular interactions in the context of mechanisms of tumorigenesis may be assigned to F09A. Applications that focus on structural and functional analysis using biophysical methods and computational approaches may be assigned to F04B.
There are shared interests with the Cell Biology, Developmental Biology and Bioengineering (F05) fellowship panel in cell and molecular biology. Applications that focus on oncogenesis may be assigned to F09A. Applications that use cancer cells as a model to study normal cell and molecular biology may be assigned to F05.
There are shared interests with the Genes, Genomes, and Genetics (F08) fellowship panel in DNA damage/repair, genetics and epigenetics. Grant applications that focus on how these processes are altered in oncogenesis may be assigned to F09A. Applications that use cancer cells as a model to study normal mechanisms of DNA damage/repair, genetics and epigenetics may be assigned to F08.