The F05 panel reviews fellowship applications in the broad areas of molecular, cellular, and developmental biology when the focus is to understand basic principles of cell structure, function, regulation and differentiation. Genetic applications with a cell biology focus and most bioengineering and technology-based applications in the basic sciences are also reviewed in F05. It encompasses many of the scientific disciplines covered by the Cell Biology [CB] and Bioengineering Sciences and Technologies [BST] integrated review groups.
- Membrane structure, function and trafficking, including organelle biogenesis and autophagy
- Cytoskeletal dynamics and motility
- Cell cycle regulation, including mitosis, meiosis, apoptosis and cell senescence
- Nuclear organization and transport, and chromatin structure and function
- Gene expression and regulation (includes RNA localization and trafficking)
- Protein stability, turnover and degradation
- Cellular signaling and regulatory systems
- Developmental cell biology, including germ and stem cell biology
- Biomaterials, nanomaterials, tissue engineering, and biological delivery systems
- Computational biology, cellular imaging, image processing, and data mining
- Devices and detection systems
- Anterior and posterior eye biology (retina and lens)
Shared Interests and Overlaps
Fellowship panels are broad and cover inter-related areas. Assignments are made based on the primary emphasis of the proposed research and topics in several fellowship panels overlap as described below. Final assignments are made by the staff at the Center for Scientific Review to ensure that each application has the appropriate expertise to review it.
There are shared interests with Genes, Genomes, and Genetics (F08). Applications with a focus on cellular processes may be assigned to F05, whereas applications having a strong genetic focus may be assigned to F08.
In the areas of cancer biology, there are shared interests with fellowship panels in the Oncology 1 – Basic Translational (OBT) integrated review group. Applications that use cancer cells as a model to study normal cell and molecular biology may be assigned to F05, whereas applications that focus on oncogenesis may be assigned to Oncological Sciences A (F09A). Applications that focus on the development of new biomaterials, engineered tissues, or drug delivery systems may be assigned to F05, whereas applications that use biomaterials and engineered tissues to answer biological questions in the oncology field may be assigned to Oncological Sciences B (F09B). Applications that use biomaterials and engineered tissues to answer biological questions in tumor immunology or immunotherapy may be assigned to Oncological Sciences C (F09C).
There are shared interests with Musculoskeletal and Skin Sciences, Bioengineering, Imaging, Surgery, and Informatics (F10B). Applications that focus on fundamental aspects of bioengineering and technology development may be assigned to F05, whereas applications at the interface between a physical science or engineering and biomedical or clinical research may be assigned to F10B.