The Cellular and Molecular Immunology B (CMIB) Study Section reviews the basic function/structure of the adaptive immune system and interplay with innate responses. Emphasis is on the activation, development, differentiation, cell-cell interactions and organs of the immune system (e.g. thymus, bone marrow, spleen, liver, lymph nodes, gut associated lymphoid tissues or GALT) through both molecular, cellular and biochemical approaches.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Functional and structural mechanisms of leukocyte (T cells, B cells, NKT cells, NK cells, dendritic cells and monocytes) development, differentiation, cell/cell interactions, homeostasis and receptors in primary, secondary and tertiary lymphoid areas (thymus, bone marrow, lymph nodes, skin, mucosa, Peyers Patches, GALT, spleen, and peripheral blood.
- Initiation and immunologic recall of adaptive immune responses in antigen processing/presentation, interactions with innate immune responses, signal transduction, pre- and post-transcriptional gene regulation and translation, epigenetics in development.
- Signal transduction during activation, surface receptor activation and cytokine signaling.
- Metabolism related to immunobiology and cell development/differentiation.
- Functions and dysfunctions related to these lymphoid cells i.e. tolerance, autoimmunity, immunodeficiency leading to cancers and autoimmunity.
- Comparative immunology found in non-mammalian systems.
Shared Interests and Overlaps
There are shared interests with Cellular and Molecular Immunology A (CMIA) in basic cellular and molecular aspects of immunology. Applications with focus on structural, functional and biochemical aspects of cellular, molecular, and biochemical interactions of the immune response and immunotherapies, including but not limited to x-ray crystallography may be assigned to CMIA. Applications related to V(D)J rearrangement, basic immune cell development, activation, differentiation and functional studies may be assigned to CMIB.
There are shared interests with Innate Immunity and Inflammation (III) in signaling pathways leading to cell activation and differentiation. Applications with focus on the differentiation of innate cells and innate immunity may be assigned to III. Applications focusing on antigen processing, presentation and adaptive immunity may be assigned to CMIB.
There are shared interests with Hypersensitivity, Autoimmune, and Immune-mediated Diseases (HAI) in basic immune mechanisms. Applications concerning autoimmune responses and autoimmune mechanisms may be assigned to HAI. Applications focusing on the basic aspects of immunology related to autoimmunity, such as lack of negative selection in T and B cells, may be assigned to CMIB.
There are shared interests with Immunity and Host Defense (IHD) in immune responses and functions. Applications with focus on immune responses to specific pathogens may be assigned to IHD. Applications focusing on the more basic molecular, cellular and biochemical nature of the immune response may be assigned to CMIB.
There are shared interests with Vaccines against Microbial Diseases (VMD) in basic immune mechanism and responses. Application focusing on the immunologic process of vaccine design, development and testing may be assigned to VMD. Applications focusing on the mechanisms of basic immunobiology and memory T and B cell development may be assigned to CMIB.
There are shared interests with Transplantation, Tolerance, and Tumor Immunology (TTT) immune cell differentiation and functions. Applications with direct focus on transplantation immunology, immunotherapies and tumor immunology may be assigned to TTT. Applications focusing on lymphocyte dysfunction in differentiation as it applies to tolerance and tumors may be assigned to CMIB.
There are shared interests in cytokine signaling with Receptor Biology and Signal Transduction (RBST). Applications focused on cytokine signaling in mediating immune response are reviewed in CMIB. Applications focused on cytokine mediated receptor activation and signal transduction pathways are reviewed in RBST.
There are shared interests in mechanisms that regulate immune responses with Cellular Signaling and Regulatory System (CSRS). Applications that emphasize the immunological outcomes are reviewed in CMIB. Applications that emphasize intracellular signaling mechanisms related to propagation and attenuation of immune responses with respect to cellular physiology are reviewed in CSRS.