Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section – HTBT
HTBT reviews applications involving basic and applied aspects of hemostasis, thrombosis, hematopoiesis, red blood cells, white blood cells, platelets, and transfusion. Studies using cellular, biochemical, biophysical, immunological, genetic, pharmacological and molecular biological approaches to define normal and pathological processes are reviewed. Applied aspects of normal and abnormal hematopoiesis, as well as applied aspects of the formed elements of the blood are also reviewed. Additional areas of review include hematopoietic stem cells, hematopoietic growth factors and their receptors, iron and heme metabolism, blood cell cytoskeleton biology, myeloid biology, transfusion medicine and gene therapy. HTBT does not review applications related to leukemia. These will typically be reviewed in the OBT/ OTC IRGS.
Review Dates
Topics
- Mechanisms of hemostasis, thrombosis and blood coagulation.
- Hematopoiesis, including hematopoietic stem and progenitor cells and epigenetic regulation of gene expression.
- “Omics” of blood cells and plasma proteins related to hematologic diseases.
- Thrombolysis/fibrinolysis, Plasminogen activation, sepsis, proteases and their receptors.
- Platelet and Megakaryocyte biology, congenital and acquired platelet/bleeding disorders and their gene therapy.
- Pathogenesis and pathophysiology of thromboembolism, thrombophilia, thromboembolism and related diseases. Thrombogenesis and coagulation in inflammation/immune response and cancer/uncontrolled tissue growth, acquired coagulopathies.
- Transfusion medicine, blood substitutes; blood banking; development of globin gene regulation, immunohematology.
- Inherited or acquired anemias including sickle cell anemia, sideroblastic anemias, hemolytic anemias, anemia of chronic disease and anemias of bone marrow failure. Inherited or acquired bleeding and thrombotic disorders, including hemophilia. Iron and heme metabolism and iron overload states.
- Thrombocytopenia due to aplastic anemia, lymphoma, Wiskott-Aldrich or May-Hegglin syndrome, viral infection and chemotherapy or radiation treatments.
- Leukocyte biology and diseases (not including leukemia): Leukocyte adhesion, migration and release of bioactive factors and related roles in capillary permeability, vasomotor response, blood clotting, inflammation, tissue repair and remodeling, fibroblast activation and scar formation.
- Myelopoiesis, erythropoiesis, leukopoiesis and thrombopoiesis.
Shared Interests and Overlaps
HTBT and Atherosclerosis and Vascular Inflammation (AVI) have shared interests in thrombosis. Applications that emphasize atherothrombosis in terms of atherosclerotic plaque rupture will be reviewed in AVI. Applications that emphasize other thrombosis- related subjects will be reviewed in HTBT.
HTBT and Basic Biology of Blood, Heart and Vasculature (BBHV) have shared interests in blood research. Applications that emphasize basic blood cell biology, structure, omics, and behavior will be reviewed in BBHV. Applications that emphasize the mechanism of action, the involvement of blood cells in disease and all non-clinical transfusion related applications will be reviewed in HTBT.
HTBT and Clinical Integrative Cardiovascular and Hematological Sciences (CCHS) have shared interests in transfusion medicine. Applications that emphasize clinical studies in transfusion medicine will be reviewed in CCHS. Applications that emphasize all other transfusion medicine applications will be reviewed in HTBT.
HTBT and Surgery, Anesthesiology, and Trauma Study Section (SAT) have shared interests in sepsis. Applications that emphasize involving sepsis and surgery, injury, or surgical critical care will be revived in SAT. Applications that empathize involving sepsis and coagulation mechanism or effects will be reviewed in HTBT.
HTBT has shared interests with Brain Injury and Neurovascular Pathologies (BINP) in neural injury. Applications that emphasize mechanisms of traumatic brain injury and stroke will be assigned to BINP (animal studies) or ANIE (human subject studies). Applications that emphasize coagulation factors in intracranial hemorrhage/clot formation will be reviewed in HTBT.
HTBT and Intercellular Interactions (ICI) have shared interests in cell adhesion. Applications that emphasize cellular interactions through cell adhesion will be reviewed in ICI. Applications that emphasize cell adhesion involved in platelet aggregation and thrombosis will be reviewed in HTBT.
HTBT and Development-2 (DEV2) have shared interests in in hematopoietic stem cell biology. Applications that emphasize hematopoietic stem and progenitor cells during early embryonic hematopoietic development will be reviewed in DEV2. Applications that emphasize hematopoietic stem and progenitor cells in hematopoiesis, transplantation, homing, migration, and gene therapy will be reviewed in HTBT.
