The Development-2 [DEV2] study section reviews applications covering a wide range of topics in developmental biology using diverse animal models. Cell biological, biochemical, genetic, imaging and molecular approaches to developmental problems at the level of cells, tissues, organs and the whole organism are appropriate. Emphasis is on pattern formation, stem cell biology, evolution, birth defects, and early embryonic development.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Stem cell biology: embryonic stem cells, hematopoietic stem cell and mesenchymal stem cell development, stem cell commitment and differentiation, epigenetics in stem cell differentiation
- Totipotency, Pluripotency, induced pluripotency (reprogramming).
- Early embryonic development: establishment and maintenance of cell polarity in eggs and embryos; tracing of cell lineage; cell migration; gastrulation; epithelial-mesenchymal transformation.
- Pattern formation: the process of cells establishing and refining boundaries and cellular identities that lead to morphological and biochemical patterns; the analysis of signal transduction pathways and signal integration during development.
- Regulatory networks: whole genome approaches to profile and analyze regulatory networks in development particularly in the context of pattern formation, birth defects, early embryonic development.
- Evolution of development: comparative development to understand conserved developmental processes and how they evolved.
- Birth defects: mechanism-based analyses of birth defects.
Shared Interests and Overlaps
There are shared interests with Development-1 (DEV1) in stem cell biology. Applications studying pluripotency and totipotency are reviewed in DEV2, and those with a focus on differentiation into germ layers and tissue formation are reviewed in DEV1
There are shared interests with Intercellular Interactions (ICI). Applications studying signaling pathways to mediate cell-cell interactions are reviewed in ICI. Applications studying cell-cell interaction in early embryonic development are reviewed in DEV2
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in cellular processes such as cell proliferation and cell death. Applications about basic mechanisms of these process are reviewed in CSRS. Studies where involvement of these processes in early embryonic development is the focus are reviewed in DEV2
There are shared interests with Molecular Genetics (MGB) in epigenetics and gene regulatory networks. Applications studying basic epigenetics and gene regulatory mechanisms are reviewed in MGB, and applications studying role of these processes in stem cell biology and early embryonic development are reviewed in DEV2
There are shared interests with Skeletal Biology Development and Disease (SBDD). Applications that focus on studying regulatory networks in patterning of craniofacial and skeletal tissues during embryonic development are reviewed in DEV2. Applications studying craniofacial and skeletal development and patterning may be reviewed in SBDD
There is shared interest with Neurogenesis and Cell Fate (NCF) and Neurodifferentiation, Plasticity, Regeneration and Rhythmicity (NDPR) in neuronal development.
There are shared interests with Molecular and Cellular Hematology (MCH) in hematopoietic stem cell biology. Applications focused on hematopoietic stem and progenitor cells during early embryonic hematopoietic development may be assigned to DEV2. Applications involving hematopoietic stem and progenitor cells in hematopoiesis, transplantation, homing, migration, and gene therapy may be assigned to MCH.
There are shared interests with Cellular, Molecular and Integrative Reproduction (CMIR) in stem cell biology, embryonic stem cells, and early embryonic development. Grant applications that focus on gamete stem cells and early embryo development through blastulation may be assigned to CMIR. Applications focused on embryo development and somatic stem cell biology in a developmental context may be reviewed by DEV2