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Innate Immunity And Inflammation Study Section [III]

The Innate Immunity and Inflammation (III) Study Section reviews applications involving fundamental aspects of innate immunity with focus on the activation and regulation of innate immune signaling in systemic and tissue-specific inflammation in the host response to pathogens or commensals and in sterile inflammation.

Rosters

Topics

  • Recruitment, activation, and effector functions of innate immune cells such as neutrophils, macrophages, monocytes, dendritic cells, and NK cells. Basic studies of innate-like lymphocytes involved in systemic and tissue-specific inflammation may also be considered.
  • Animal and in vitro models of innate immunity and inflammation; non-mammalian models and plant systems of innate immunity, and systems biology approaches to understand the activation and regulation of innate immune signaling.
  • Pattern recognition receptor (PRR) pathways; inflammasome formation and activation; PRR interactions with pathogen-associated molecular pat¬terns (PAMPs) and damage-associated molecular patterns (DAMPs), and PRR crosstalk.
  • Phagocytosis and autophagocytosis including phagosome, autophagosome, and phago-lysosome formation and processes.
  • Effector molecules and their receptors such as adhesion molecules, cytokines, chemokines, lipid mediators, other autocoids, anti-microbial peptides, and complement.
  • Innate immune regulation of adaptive immune responses, including transcription factor activation and entry into the nucleus, cytokine, chemokine, and co-stimulatory molecule production, pathogen binding to endocytic PRRs and delivery to endosomes and lysosomes.

Shared Interests and Overlaps

There are shared interests with Immunity and Host Defense (IHD). Applications with focus on host defense to deleterious effects of pathogens and applications at the innate-adaptive interface may be assigned to IHD. Applications with focus on innate immune signaling and its regulation may be assigned to III.

There are shared interests with Cellular and Molecular Immunology A (CMIA) in cells associated with antigen presentation. Applications involving structural, molecular and cellular mechanisms of antigen processing and presentation may be assigned to CMIA. Applications involving innate immune signaling and its regulation of adaptive immune responses may be assigned to III.

There are shared interests with Cellular and Molecular Immunology B (CMIB) in signaling pathways. Applications at the interface between innate and adaptive immunity, such as NK–DC interactions and comparative immunology may be assigned to CMIB. Applications with primary focus on innate immune regulatory pathways, involving innate cells, in animal, non-mammalian, plant, and in vitro models may be assigned to III.

There are shared interests with Hypersensitivity, Autoimmune, and Immune-mediated Diseases (HAI) in innate responses. Applications involving chronic autoimmune and inflammatory diseases, including those with focus on the innate-adaptive interface, may be assigned to HAI. Applications with primary focus on innate immune regulatory pathways using autoimmune models or models of inborn errors of innate immunity may be assigned to III.

There are shared interests with Hypersensitivity, Allergies and Mucosal Immunology recurring Special Emphasis Panel (HAMI) in cells associated with inflammation. Applications involving effector functions of basophils, eosinophils, and mast cells with focus on hypersensitivities, allergic diseases and/or mucosal immunology may be assigned to HAMI. Applications with primary focus on innate immune regulatory pathways involving innate cells, using animal and in vitro models, may be assigned to III.

There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in cell signaling and regulation. Applications involving studies of cellular information processing, cellular homeostasis, and cellular physiology may be assigned to CSRS. Applications involving effector and regulatory processes in innate immune signaling pathways may be assigned to III. ​