- Division of Translational and Clinical Sciences – DTCS
- Review Branch:
- Respiratory, Cardiac, and Circulatory Sciences – RCCS
Dr. Stefania Senger earned her PhD in genetics from the University Federico II in Italy, and completed her training in molecular genetics as a visiting research fellow at NIH, where she studied the molecular mechanisms underlying maintenance and differentiation of the germline stem cells. Dr. Senger turned her research interests to mucosal biology while at the Italian Institute of Food Sciences of the National Research Council, where she studied the adaptive immune response to gluten in in celiac disease (gluten intolerance). In 2013 she was appointed as faculty at Mass General Brigham/Harvard Medical School where she set up an organoids’ biorepository derived from patient intestinal biopsies to study how the intestinal microenvironment shapes epithelial responses and contributes to the pathology of intestinal diseases including celiac disease, necrotizing enterocolitis and enteropathogen infection. Her work has been supported by NIH, Massachusetts General Hospital, and industry sponsorship. Her scientific interests include stem cell and mucosal biology, genetics, host-microbial interaction, and autoimmune diseases.