Development - 2 Study Section – DEV2
The Development-2 [DEV2] study section reviews applications covering a wide range of topics in developmental biology using diverse animal models. Cell biological, biochemical, genetic, imaging and molecular approaches to developmental problems at the level of cells, tissues, organs and the whole organism are appropriate. Emphasis is on pattern formation, stem cell biology, evolution, birth defects, and early embryonic development.
Review Dates
Topics
- Stem cell biology: embryonic stem cells, hematopoietic stem cell and mesenchymal stem cell development, stem cell commitment and differentiation, epigenetics in stem cell differentiation
- Totipotency, Pluripotency, induced pluripotency (reprogramming).
- Early embryonic development: establishment and maintenance of cell polarity in eggs and embryos; tracing of cell lineage; cell migration; gastrulation; epithelial-mesenchymal transformation.
- Pattern formation: the process of cells establishing and refining boundaries and cellular identities that lead to morphological and biochemical patterns; the analysis of signal transduction pathways and signal integration during development.
- Regulatory networks: whole genome approaches to profile and analyze regulatory networks in development particularly in the context of pattern formation, birth defects, early embryonic development.
- Evolution of development: comparative development to understand conserved developmental processes and how they evolved.
- Birth defects: mechanism-based analyses of birth defects.
Shared Interests and Overlaps
There are shared interests with Development-1 (DEV1) in stem cell biology. Applications studying pluripotency and totipotency are reviewed in DEV2, and those with a focus on differentiation into germ layers and tissue formation are reviewed in DEV1
There are shared interests with Intercellular Interactions (ICI). Applications studying signaling pathways to mediate cell-cell interactions are reviewed in ICI. Applications studying cell-cell interaction in early embryonic development are reviewed in DEV2
There are shared interests with Skeletal Biology Development and Disease (SBDD). Applications that focus on studying regulatory networks in patterning of craniofacial and skeletal tissues during embryonic development are reviewed in DEV2. Applications studying craniofacial and skeletal development and patterning may be reviewed in SBDD
There is shared interest with Neurogenesis and Cell Fate (NCF) and Neurodifferentiation, Plasticity, Regeneration and Rhythmicity (NDPR) in neuronal development.
DEV2 and Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section (HTBT) and have shared interests in hematopoietic stem cell biology. Applications that emphasize hematopoietic stem and progenitor cells during early embryonic hematopoietic development will be reviewed in DEV2. Applications that emphasize hematopoietic stem and progenitor cells in hematopoiesis, transplantation, homing, migration, and gene therapy will be reviewed in HTBT.
There are shared interests with Cellular, Molecular and Integrative Reproduction (CMIR) in stem cell biology, embryonic stem cells, and early embryonic development. Grant applications that focus on gamete stem cells and early embryo development through blastulation may be assigned to CMIR. Applications focused on embryo development and somatic stem cell biology in a developmental context may be reviewed by DEV2
