Clinical Integrative Cardiovascular and Hematological Sciences – CCHS

Topics

• Human clinical studies, including pediatric populations, cardiovascular imaging, mechanisms and consequences of disease. Investigations may include physiology, pharmacology, electrophysiology, regional circulation, transfusion medicine, blood cell abnormalities, hemodynamics, cardiac mechanics, biomarker discovery, and genetic considerations in cardiovascular studies.
• Disease states may include cardiac and vascular ischemia, heart failure/cardiomyopathy, metabolic syndrome, atherosclerosis, stroke, dyslipidemia, hypertension, obesity, diabetes, thyroid disease, general inflammation, hypercholesterolemia, and hematologic disorders such as sickle cell disease and hemophilia.
• Modulation of cardiac/cardiovascular responses and adaptations including influence of sex, aging, pregnancy, and acute/chronic exercise on metabolic function and cardiac, vascular smooth muscle, and vascular endothelial function(s).
• Neural control of the cardiovascular system including central and peripheral autonomic physiology, pharmacology, and receptor mechanisms in healthy and diseased populations.
• Clinical studies investigating the responses of the cardiovascular system to trauma or surgery including arrhythmias associated with cardiac surgery or cardiopulmonary bypass, cardiac sudden death, resuscitation, stenting, pacemakers, cardiovascular injury and repair, and myocardial ischemia/reperfusion injury.
• Environmental stresses, cardiovascular toxicity, and modifying conditions/stimuli including smoking, altitude, microgravity, heat, cold, bed rest/deconditioning, and environmental pollution in patients.

Shared Interests and Overlaps

There are shared interests in hematologic disorders with Cancer and Hematologic Disorders (CHD). Clinical studies of the pathology associated with hematological dysfunction typically with small sample sizes are reviewed in CCHS. Applications that emphasize epidemiologic studies of hematologic disorders and clinical trials aimed at answering population-based questions about hematologic disease development, progression and treatment outcomes are reviewed in CHD. 

CCHS and Integrative Myocardial Physiology/Pathophysiology A (MPPA) have shared interests in heart failure and cardiomyopathy. Applications that emphasize basic and translational aspects of heart failure/cardiomyopathy, typically in animal models, will be reviewed in MPPA. Applications that emphasize clinical aspects of heart failure and cardiomyopathy in humans and human samples will be reviewed in CCHS.

CCHS and Integrative Vascular Physiology and Pathology (IVPP) have shared interests in topics related to blood pressure regulation, hypertension, neural control of the cardiovascular system, and micro- or regional circulation. Applications that emphasize the basic and translational aspects of these topic areas, typically in animal models, will be reviewed in IVPP. Applications that emphasize on clinical aspects of these topic areas in humans and human samples will be reviewed in CCHS.

CCHS and Atherosclerosis and Vascular Inflammation (AVI) have shared interests in topics related to atherosclerosis and inflammation of the vascular system. Applications that emphasize basic and translational aspects of these topic areas in cellular and animal models will be reviewed in AVI. Applications that emphasize clinical aspects of atherosclerosis and vascular inflammation in humans and human samples will be reviewed in CCHS.

CCHS and Human Studies of Diabetes and Obesity (HSDO) have shared interests in topics related to diabetes and obesity in humans. Applications that emphasize non-cardiovascular research applications related to diabetes and obesity will be reviewed in HSDO. Applications that emphasize on cardiovascular complications and endpoints related to diabetes and obesity will be reviewed in CCHS.

There are shared interests in aging effects on cardiac physiology, modulation of cardiac response, neural control of the cardiovascular system, and treatments of heart disease with Aging Systems and Geriatrics (ASG). Applications that emphasize aging effects in human subjects on cardiac topics are reviewed in CCHS. Applications that emphasize aging effects as outcomes or effects of geriatric syndromes, including dementias, failure to thrive, multi-morbidity and polypharmacy are reviewed in ASG as well as applications that emphasize pleiotropic interventions that include cardiac endpoints as outcomes.

CCHS and Therapeutic Development and Preclinical Studies (TDPS) have shared interests in human, patient-oriented studies. Applications that emphasize both animal models and human subjects, where the goal is largely pre-clinical, including resuscitation studies in animal models, will be reviewed in TDPS. Applications that emphasize studies in humans, in the context of clinical research/trials will be reviewed in CCHS.

CCHS and Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section (HTBT) have shared interests in transfusion medicine. All applications that emphasize non-clinical transfusion medicine studies will be reviewed in HTBT. Applications that emphasize clinical studies in transfusion medicine will be reviewed in CCHS.

CCHS and Surgery, Anesthesiology and Trauma Study Section (SAT) have shared interests in applications proposing investigations of ischemia reperfusion injury. Grant applications that focus on tissue, organ/multiorgan and systemic ischemia reperfusion injury, and that focus on host response including hormonal, metabolic, and immune response to ischemia reperfusion injury may be assigned to SAT. Applications that focus on patients oriented research on cardiovascular injury and repair, and myocardial ischemia/reperfusion injury may be assigned to CCHS.

There are shared interests between CCHS and Bioengineering, Technology and Surgical Sciences (BTSS) in the areas of the cardiovascular system. Applications which focus on clinical, population, or translational studies of the responses of the cardiovascular system to trauma or surgery: arrhythmias associated with cardiac surgery or cardiopulmonary bypass, cardiac sudden death, resuscitation, stenting, pacemakers; cardiovascular injury and repair, and myocardial ischemia/reperfusion injury are appropriate for CCHS. Applications which focus on aspects of cardiovascular surgery may be assigned to BTSS.

There are shared interests in respiratory conditions with Cardiovascular and Respiratory Diseases (CRD). Applications that emphasize to studying physiologic and/or mechanistic aspects of pulmonary conditions using both animal models and a more patient-oriented rather than population-oriented approach to clinical populations are reviewed in RIBT. Applications that emphasize the distribution and determinants of respiratory diseases conditions in human subpopulations with an epidemiological approach are reviewed in CRD.