The Macromolecular Structure and Function B (MSFB) study section reviews applications that involve a broad range of biochemical, biophysical, and computational modeling approaches to address basic structure-function relationships in a variety of biological systems. The emphasis is on elucidating structural and dynamical characteristics of individual proteins and nucleic acids, and their complexes, and how those properties affect function of the molecules.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- RNA structure and dynamics; RNA-protein interactions, RNA catalysis, folding and splicing, ribozyme-based therapeutics, and aspects of ribosomal structure and function.
- DNA structures, including of those of chemically modified DNAs, structural analyses of DNA replication components, transcription and repair processes, DNA or RNA based genome editing systems and other aspects of protein-DNA systems such as the effects of protein folding or post-translational and epigenetic marks on protein-DNA interactions.
- Properties of proteins: structural dynamics of proteins, folding and misfolding processes; engineering proteins to enhance function, allostery and cooperativity in enzyme mechanism and control, chaperones, thermodynamic and electrostatic features of protein function.
- Components of signal transduction systems such as circadian rhythm proteins, chemokines and their receptors, kinases and phosphatases.
- Structural and functional effects of protein post-translational modifications and the regulation of these (e.g. protein glycosylation, ubiquitination, sumoylation, phosphorylation, methylation and other modifications)
Shared Interests and Overlaps
There are shared interests for applications involving macromolecular biophysics and structural biology with Macromolecular Structure and Function A (MSFA), Macromolecular Structure and Function C (MSFC), Macromolecular Structure and Function D (MSFD) and Biochemistry and Biophysics of Membranes (BBM). Applications focused on structural or biophysical analyses of RNA molecules, complexes or ribozymes, protein-nucleic complexes, biophysical properties of proteins, misfolded or unstructured proteins, or post-translational modifications of proteins may be assigned to MSFB.
There are shared interests with Membrane Biology and Protein Processing (MBPP) in the areas of protein/misfolding. Applications studying protein folding/misfolding using biophysical approaches are reviewed in MSFB and those using biochemical and molecular approaches of are reviewed in MBPP
There are shared interests with Molecular Genetics A (MGA) and Molecular Genetics B (MGB). Applications involving structure and function studies of RNA, DNA and protein nucleic acid complexes where the focus is primarily directed towards characterizing the structural and biophysical aspects may be assigned to MSFB while applications that involve more focus on the function of the molecules in the context of the host organism may be assigned to MGA or MGB
There are shared interests with Prokaryotic Cell and Molecular Biology (PCMB). Applications involving structure function studies of prokaryotic molecules may be reviewed by MSFB studies that focus on bacterial processes that also include structural methods maybe reviewed by PCMB.