The Macromolecular Structure and Function A (MSFA) Study Section reviews applications that focus on the structure and structure-function relationships of enzymes and their complexes, interactions between enzymes and their effectors and substrates, the biochemistry and biophysics of metal center containing proteins, regulation of metal ion concentration and biochemical mechanism/structure based drug development. A broad range of physical, chemical, genetic, kinetic, mechanistic, thermodynamic and theoretical approaches are covered. The most commonly used experimental methods are NMR, EPR, crystallography, laser spectroscopy and electron microscopy.
The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Mechanistic enzymology involving protein and nucleic acid catalysts.
- The design, synthesis and use of enzyme inhibitors where the primary interest is to understand or modulate enzyme mechanism/function. Biochemical mechanism based drug development.
- Protein-ligand interactions and dynamics.
- Macromolecular studies of metabolic pathways and networks.
- Computational and theoretical studies of biochemical reactions, application of quantum mechanics and molecular mechanics to studies of enzyme mechanisms, genomic enzymology, sequence-structure analysis to uncover mechanistic strategies of superfamilies.
- Metalloenzymes and their mechanisms: biochemical, spectroscopic, genetic, kinetic and structural methods applied to understand the mechanism of the metal center. Synthetic and theoretical models of metallo-active sites: small molecule complexes and designed peptides intended to mimic an enzyme active site reactivity or metal center specificity.
- Chemistry of metal centers and organic redox active cofactors: redox chemistry of oxygen/nitrogen species. Chemistry of reactive oxygen/nitrogen metabolism: methods of generation and mitigation as well as it undesired side reactions.
- Metal ion homeostasis and metabolism: regulation of influx, efflux and transport of iron, copper, zinc and manganese as well as other metals ions whose concentration must be closely controlled or limited. Mechanisms of metal ion toxicity.
Shared Interests and Overlaps
There are shared interests for applications involving macromolecular biophysics and structural biology with Macromolecular Structure and Function B (MSFB), Macromolecular Structure and Function C (MSFC), Macromolecular Structure and Function D (MSFD) and Biochemistry and Biophysics of Membranes (BBM). Applications focused on details of enzyme mechanisms, redox chemistry, metalloenzymes and metal binding proteins, or protein-ligand interactions may be assigned to MSFA.
There are shared interests for applications involving natural product biosynthesis with Synthetic and Biological Chemistry B (SBCB). Applications focused on enzyme mechanism of biosynthetic pathway components may be assigned to MSFA while applications focused on overall chemistry and end products or their derivatives may be assigned to SBCB.
There are shared interests with Prokaryotic Cell and Molecular Biology (PCMB). Applications involving biophysical and biochemical analysis of metal ion containing proteins or enzymology of prokaryotic molecules may be reviewed by MSFA studies that focus on bacterial processes that also include structural methods maybe reviewed by PCMB.