The Pathogenic Eukaryotes (PTHE) Study Section reviews applications involving protozoal, helminthic and fungal pathogens in humans and animal models. Applications may address a wide variety of biological issues related to eukaryotic pathogens including cell biology, biochemistry, immunology, physiology, and genetics.
The List of Reviewers lists all present, whether permanent or temporary, to provide the full scope of expertise present on that date. Lists are posted 30 days before the meeting and are tentative, pending any last minute changes.
The membership panel is a list of chartered members only.
- Mechanisms of pathogenesis including: pathogen-host cell receptor interactions, signaling pathways in both host cell and pathogen, molecular mechanisms of virulence, manipulation of host cell biological pathways, and factors associated with asymptomatic infection and/or commensalism.
- Host-microbe interaction mechanisms including innate host immune responses to eukaryotic pathogens, genetic resistance and susceptibility to infection and disease, induction and regulation of innate immunity, immunopathology, and evasion of host immune responses.
- Biochemical processes of the pathogen including: metabolism, enzymology, and physiology.
- Identification and initial characterization of potential chemotherapeutic targets and diagnostic strategies.
- Eukaryotic pathogen cell biology including: organelle function, novel organelles, secretory processes, mechanisms of motility, host cell invasion, and the establishment of intracellular infection and replication.
- Eukaryotic pathogen differentiation, morphogenesis, and developmental processes required for the infectious cycle including transmission and persistence.
- Eukaryotic pathogen genetic processes (gene structure, regulation of gene expression, molecular evolution, genetic diversity, and improved genetic methodology).
- Functional genomics, comparative genomics, proteomics, and other broad-based technologies for studying eukaryotic pathogen genomes.
- Improved models of infectious cycles and diseases.
Overlaps with Closely Related Study Sections
There are shared interests with Drug Discovery and Mechanisms of Antimicrobial Resistance (DDR) in the investigations of the process of infections by eukaryotic pathogens. Grant applications that focus on the development of drugs that address infections of eukaryotic pathogens may be reviewed in DDR. Applications that seek new therapeutic targets against eukaryotic pathogens through basic studies that focus on pathogen physiology may be reviewed in PTHE.
There are shared interests with Immunity and Host Defense Study Section (IHD)in the investigations of the process of infections by eukaryotic pathogens. Grant applications that focus on the innate and acquired immune responses to eukaryotic pathogens including a focus on immune cells may be reviewed in IHD. Applications that emphasize the interactions between the host and the eukaryotic pathogen may be reviewed in PTHE.
There are shared interests with Vector Biology Study Section (VB) in the investigations of the process of infections by eukaryotic pathogens. Grant applications that focus on interactions between eukaryotic pathogens and their vectors may be reviewed in VB. Applications that focus on the biology of the eukaryotic pathogens inside the vectors may be reviewed in PTHE.
There are shared interests with Genetic Variation and Evolution Study Section (GVE) in the area of eukaryotic pathogen-host interactions. Grant applications that focus on such interactions as a coevolution process using genomic, genetic or computational methods may be reviewed in GVE. Applications that focus on genetic factors involved in the molecular mechanisms of such interactions may be reviewed in PTHE.
There are shared interests with Clinical Research and Field Studies of Infectious Diseases (CRFS)in the general area of eukaryotic pathogens. Grant applications that focus on population-based studies examining human-eukaryotic pathogen interaction, epidemiology or diagnostics of eukaryotic pathogens may be reviewed in CRFS. Applications that focus on mechanistic in vitro studies and animal models of eukaryotic pathogens may be reviewed in PTHE.
There are shared interests with Vaccines against Microbial Diseases (VMD) in the process of eukaryotic pathogen infections. Grant applications that explore a late stage of vaccine development against such pathogens may be reviewed in VMD. Applications that address early stage vaccine issues such as developing vaccine candidates or exploring molecular levels of eukaryotic pathogenesis may be reviewed in PTHE.