The Biochemical and Cellular Oncogenesis (BCO) study section focuses on the proteins and signal transduction pathways that drive the initiation or early stages of human cancer. A distinguishing characteristic of applications are the use of multidisciplinary approaches to characterize the structure, function, and modulation of oncogenic proteins that participate in and integrate diverse signaling networks.
The membership panel is a list of chartered members only.
- Characterization of oncogenes and tumor suppressors in tumor initiation and transformation.
- Effects of post-translational modifications on protein stability, structure and function in the context of cancer.
- Integration of aberrant or deregulated protein signaling pathways in tumor initiation, including dissection of protein complexes and signaling networks.
- Protein target discovery within oncogenic signaling pathways.
- Chemical biology and genetic approaches to interrogate protein-protein interactions or signaling pathway function in early tumorigenesis.
- Role of cell cycle pathways in early tumorigenesis.
Shared Interests and Overlaps
There are shared interests with Gene Regulation in Cancer (GRIC) in the role of oncogenes and tumor suppressors in tumorigenesis. Applications that focus on gene regulatory mechanisms and epigenetics may be reviewed in GRIC. Applications that focus on tumor initiation, signal transduction and post-translational modifications may be reviewed in BCO.
There are shared interests with Cancer Etiology (CE) in the investigation of post-translational modifications. Applications that focus on post-translational modifications in the context of DNA damage/repair may be reviewed in CE. Applications that focus on post-translational modification processes that contribute to cellular transformation and early oncogenesis may be reviewed in BCO.
There are shared interests with Cancer Cell Biology (CCB) in basic mechanisms of cell cycle pathways, signal transduction and tumorigenesis. Applications that mainly focus on mechanisms associated with tumor metabolism, stress and cell death may be reviewed in CCB. Applications that mainly focus on tumor initiation and post-translational modifications may be reviewed in BCO.
There are shared interests with Mechanisms of Cancer Therapeutics A, B, C in mechanisms involved in early stages of tumorigenesis. Applications that focus on mechanistic studies of the effects of anti-neoplastic agents as therapeutics on early tumorigenesis may be reviewed in the MCTs. Applications that focus on using anti-neoplastic agents as tools to examine basic mechanisms involved in early tumorigenesis may be reviewed in BCO.
There are shared interests with Cellular Signaling and Regulatory Systems (CSRS) in cell cycle and signaling pathways. Applications that focus on the normal, or cancer cells as a model to understand basic mechanisms underlying these processes are reviewed in CSRS. Applications that focus on oncogenic transformation and tumor initiation may be reviewed in BCO.