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Aging Systems and Geriatrics Study Section [ASG]

The Aging Systems and Geriatrics (ASG) study section reviews grant applications on many different disorders linked by an emphasis on investigating the disorder(s) in the context of aging. It reviews studies of neurological (especially cognitive), endocrine, orthopedic, cardiovascular, pulmonary etc. disorders in aging. Proposals to investigate geriatric syndromes that affect, or reflect, multiple organ systems such as frailty, incontinence, loss of functional capacity, and delirium are reviewed. It also reviews investigations of factors influencing life span and rates of aging changes. Proposals are typically clinical-translational efforts (including interventional clinical trials) but proposals using primate, canine, murine and other animal models with a translational emphasis are also reviewed.



  • Age-related changes in the regulation of complex physiological functions (e.g., motor performance, balance, glucose metabolism, immune defense, menopause, and interventions to ameliorate such age-related changes)
  • Falls, syncope, frailty, immobility, malnutrition, sarcopenia, loss of functional independence, and failure to thrive.
  • Delirium, progressive cognitive impairment (mild cognitive impairment, Alzheimer’s Disease and other neurocognitive disorders)
  • Chronic pain, mood disorders, incontinence, polypharmacy in the aged
  • Multicomponent, pleiotropic (e.g., exercise, nutrition) and mechanism-driven intervention studies addressing geriatric syndromes or age-related diseases affecting multiple systems which are unique or highly prevalent in elderly people or aging animals (e.g., congestive heart failure, atrial fibrillation, hypertension, type 2 diabetes, osteoarthritis, osteoporosis).
  • Systemic impact of co-morbidities on health status and clinical outcomes in older adults.
  • Attempts to increase lifespan including caloric restriction and studies of animal models of human populations especially resistant to aging.

Shared Interests and Overlaps

Cellular Mechanisms in Aging and Development (CMAD) and ASG have shared interest in many areas. CMAD uses a range of approaches and vertebrate/invertebrate model organisms to address fundamental biological questions regarding mechanisms that regulate healthspan and lifespan vs. ASG uses mammalian species (e.g., mice and rats) and human-subject based research for both basic and translational research.

There are shared interests with Skeletal Muscle Biology and Exercise Physiology (SMEP) regarding functional studies on human mobility and exercise with aging.

There are shared interests with Musculoskeletal Rehabilitation Sciences (MRS) regarding age-related changes on human mobility and exercise with aging. Applications that focus on rehabilitative interventions aiming to improve motor performance, balance and mobility in elderly people, including mobility support devices, may be assigned to MRS.

There are shared interests with Clinical and Integrative Cardiovascular Sciences (CICS) regarding patient oriented research involving modulation of cardiac/cardiovascular responses and adaptations with aging, and age-relative diseases. Clinical applications focused on evaluating cardiac and cardiovascular conditions and diseases in geriatric populations may be appropriate for review in CICS.

There are shared interests with Hypersensitivity, Autoimmune, and Immune-mediated (HAI) and Innate Immunity and Inflammation (III) regarding age-relative changes in the adaptive and innate immune system and their impact.

There are shared interests with Clinical Neuroscience and Neurodegeneration (CNN) regarding delirium or cognitive impairment (Alzheimer’s Disease and other neurocognitive disorders). ASG is more appropriate when there is focus on the effect of diet and aging on the microbiome and from there to the brain vs CNN had enhanced expertise on neurological aspects of these diseases and disorders.

There are shared interests with Neurological, Aging and Musculoskeletal Epidemiology (NAME) which predominately reviews applications on epidemiologic research in the areas similarly reviewed by ASG primarily using genetics, genome wide association studies (GWAS), epigenetics, gene-environment interactions, and molecular genetics. ​