Clinical Neuroimmunology and Brain Tumors Study Section – CNBT

Topics

• Preclinical and clinical studies on autoimmune disorders of the nervous system. Serum and imaging biomarkers of autoimmune disorders or the nervous system and neuroimmune disorders
• Nervous system infiltration of peripheral immune cells (T cells, B cells, and monocytes) and their interactions with CNS immune cells contributing to the immune-regulatory mechanisms in neurodegenerative disorders.
• Pre-clinical or clinical studies on immunomodulatory therapy-induced pathophysiological processes in the nervous system.
• Neuroimmunology studies on viral, bacterial, fungal and parasitic diseases, immunological impact of infection on the nervous system. Chronic viral infections associated with immune-induced CNS damage and neuroinflammation.
• Neuroimmunology and inflammatory effector mechanisms in microglia, astrocytes, other neural cells.
• Studies on primary and secondary brain tumors including glioma, glioblastoma, medulloblastoma in context of neuro-immunology neuro-inflammation and/or neuro-modulatory effect on the CNS.
• Modulatory and electrophysiological strategies for altering the autonomic-immune axis in neuro-immunological and inflammatory diseases. 

Shared Interests and Overlaps

There is substantial shared interest between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT  and https://public.csr.nih.gov/StudySections/DNDA/NPA/ZRG1NPA85  study sections. Both panel review applications on neuroimmunology and neuro-inflammation. Applications that focus on developing preclinical, cellular and animal models, developing and testing therapeutic strategies modulating or modifying immunological and inflammatory processes are reviewed in CNBT while applications that emphasize on immune activation of nervous system in response to infection or injury of the nervous system are reviewed in NPA-85. 

There are shared interests between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and https://public.csr.nih.gov/StudySections/DNDA/NPB/NICT on applications study neuroimmunology in degenerative diseases. Applications that are preclinical and/or use human subjects and emphasize neuroimmune, autoimmune or neuroinflammation in neurodegenerative disorders are reviewed in CNBT. Application studying the role of immune cells assessing in risk, pathogenesis, pathophysiology of neurodegenerative diseases and organ brain crosstalk are reviewed in NICT.

There are shared interests between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and (BNRS) on applications on neuroimmunology. Applications that emphasize clinical and preclinical neuroimmunology in disease are reviewed in CNBT. Applications that emphasize neuroimmunology in context of behavior are reviewed by BNRS. 

There are shared interests  between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and https://public.csr.nih.gov/StudySections/DNDA/BN/BMGS in the role of glia in the mechanisms underlying neuro-immunological and autoimmune responses in neural diseases including demyelinating diseases, inflammatory neuropathies, and neurodegenerative disorders . Applications that emphasize the pathogenesis, progression, and treatment of CNS autoimmune demyelinating diseases are reviewed in CNBT. Applications that emphasize basic science and mechanistic studies focused on the role of glia and blood-brain barrier in the mechanisms underlying these diseases are reviewed in BMGS. 

There is shared interest between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and https://public.csr.nih.gov/StudySections/DNDA/BN/ISND  in reviewing applications that study immune signaling in response to infectious disease and autoimmune diseases. Applications focus on the mechanistic aspects of these diseases are reviewed in ISND, while progression and pathogenesis of these diseases are reviewed in CNBT.

There are shared interests in the neuroimmunology of neurodegenerative disorders between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and  (https://public.csr.nih.gov/StudySections/DNDA/NPB/NICT ) on applications that study neuroimmunology or neuroinflammation in degenerative diseases. Applications that are preclinical and/or use human subjects and emphasize neuroimmune or autoimmune disorders and consequences of infectious insults on neurodegenerative disorders are typically reviewed in CNBT. Applications focused on the role of immune cells or inflammation in the risk, pathogenesis, or pathophysiology of neurodegenerative diseases and organ-brain crosstalk may be reviewed in NICT.

There are shared interests on clinical studies on neurodegeneration between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and  (CNTN). Applications that emphasize addressing the etiology, pathophysiology, diagnosis, and progression of neurodegenerative disorders and/or their functional consequences and the mechanisms and management of human chronic neurodegenerative diseases are reviewed in CNTN.  Applications that emphasize the neuro-immunological aspects of neurodegenerative disorders are reviewed in CNBT.

There are shared interests in bacterial and viral infections of the central nervous system with (BHI) and (BV). Applications that emphasize CNS infectious diseases due to bacterial infection and bacterial-host immune or inflammatory interactions relevant to CNS diseases or disorders are reviewed in CNBT. Applications that emphasize molecular mechanistic models of bacterial infection or pathogenesis and immunity emphasizing the bacterial perspective are reviewed in BHI or BV. 

There is shared interest between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and IIDC (81) in review of applications on bacterial infections. Applications that study bacterial innate immunomodulation and pathogenesis are reviewed in IIDC (81). Applications that study neuroimmune modulation in CNS, focusing on the neuronal components, impacts on CNS outcomes like cognition are reviewed in CNBT.

There are shared interests between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT and PTHE in reviewing applications on eukaryotic pathogen (parasitic and fungal) infections of the central nervous system . Applications that emphasize immune modulation of CNS infections due to eukaryotic pathogens are reviewed in CNBT. Applications that emphasize biology of the eukaryotic pathogen infection, pathogenesis or immunity emphasizing the eukaryotic pathogen perspective are reviewed in PTHE. 

There are shared interests between https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT , MCV and VPI and  https://public.csr.nih.gov/StudySections/DPPS/IIDB/VDT in bacterial and viral infections of the central nervous system. Applications that study the neuroimmune modulation or inflammation in the CNS in response to an infectious agent are reviewed in CNBT. Applications that emphasize addressing fundamental aspects of viral and non-bacteriophage viral genetics, infection and replication are reviewed in MCV , VDT or VPI. 

There are shared interests with (AI), (IIDA (81)), and (IIB). Applications with a greater focus on fundamental aspects of the adaptive immune response or innate immune response may be reviewed in AI or IIDA (81)/IIB, respectively. Applications addressing impacts of the adaptive or innate immune system on the function and pathology relevant to diseases or disorders of the central, peripheral, and autonomic nervous system may be reviewed in CNBT.

There are shared interests with the (MAI) and https://public.csr.nih.gov/StudySections/DNDA/NPA/CNBT . Applications that focus on immunology of autoimmune mechanisms of neurologic damage may be reviewed in MAI. Applications that focus on the clinical impact of autoimmune diseases in neural tissue and CNS may be reviewed in CNBT.

There are shared interests in neural and brain tumors with (CIC). Applications that emphasize immunological aspects of brain tumors are reviewed in CNBT. Applications that emphasize cellular therapy, including stem cell transplantation, adoptive cellular therapies and their toxicities, as well as therapeutic combinations that employ adoptive and allogeneic cell transfer immunotherapy for CNS tumors (glioma, medulloblastoma, etc.) are reviewed CIC (if focus is on cellular therapies).  Cancers like glioma, glioblastoma, medulloblastoma when studying effect on CNS are reviewed in CNBT. Cancer applications on  neuro-immunology neuro-inflammation and/or neuro-modulatory effect on the CNS are reviewed in CNBT

There are shared interests in the areas of neural and brain tumors with study sections (BTC) review branch. Applications that emphasize immunological aspects of neural tissues and/or brain tumor/host interactions where the primary focus and readout are neurological function or brain pathology are reviewed in CNBT. Applications that emphasize basic mechanisms of tumor initiation, progression, metastasis and interactions between tumor cells and cells in the brain tumor microenvironment where the primary readout is tumor growth or metastasis may be reviewed in the appropriate BTC study section.

There are shared interests in the areas of neural and brain tumors with (TIO). Applications that emphasize the immunopathology of CNS tumors (glioma, medulloblastoma, etc.) are reviewed in CNBT. Applications that emphasize the development, validation and optimization of immunotherapy of CNS tumors (glioma, medulloblastoma, etc.) with the focus on non-cellular therapeutics are reviewed in TIO. 

There are shared interests in the area of brain tumor therapy with (TIR). Applications that emphasize solely the immunopathology central nervous system tumors (glioma, medulloblastoma, etc.) are reviewed in CNBT. Applications on therapeutic immune regulation and resistance of central nervous system tumors (glioma, medulloblastoma, etc.) are reviewed in TIR. 

There are shared interests in treatment of glioblastomas, medulloblastomas, neuroblastomas and gliomas with (MCTB), and (MCTC). CNS tumor applications that focus on neuroinflammation and neuro-immunological aspect are reviewed in CNBT. Applications that emphasize the central nervous system consequences due to brain tumors are reviewed in CNBT. Applications that emphasize the mechanism(s) of action of anti-neoplastic agents in brain tumors are reviewed in MCTB, and applications that focus on early preclinical investigations of efficacy and toxicity of anti-neoplastic agents are reviewed on MCTC.