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Genetic Variation and Evolution Study Section [GVE]

The Genetic Variation and Evolution [GVE] Study Section reviews grant applications related to the origin, distribution, maintenance, and evolutionary consequences of genetic variation to provide for the expansion of fundamental knowledge about living systems.  Understanding genetic variation and evolution is central to modern approaches to biomedicine, epidemiology, health, and disease.  Studies make use of mathematical models, computer simulations, viruses, microbes (prokaryotic and eukaryotic), plants, and animals, including natural populations, laboratory model systems, and humans. 



  • Applications of evolutionary principles to: biomedicine, epidemiology, health, and disease; including host-pathogen interactions, genetics of virulence or resistance, co-evolutionary dynamics, and population structure.
  • Mechanisms of evolution: selection, adaptation, mutation, recombination, gene/genome duplication, transposition, chromosomal evolution, and speciation; 
  • Genotype à phenotype mapping: genetics of complex traits in whole organisms, QTL mapping, association mapping, disease mapping, evolution of development (evo-devo), evolution of enzymes and biochemical pathways/networks, genotype-environment interactions, evolvability, and heritability;
  • Population genetics: theory, experimental approaches, and application to large genomic datasets;
  • Molecular evolution from genes to genomes:  phylogenetics, comparative genomics, bioinformatics, computational biology, modeling, and systems biology.

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